{"id":"W4390501527","doi":"10.1007/s12035-023-03892-w","title":"Neuroprotective Effects of Metformin Through AMPK Activation in a Neurotoxin-Based Model of Cerebellar Ataxia","year":2024,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Neuroprotection; AMPK; Ataxia; Cerebellum; Metformin; Neuroinflammation; Medicine; Cerebellar ataxia; Neuroscience; Internal medicine; Endocrinology; Chemistry; Inflammation; Protein kinase A; Biology; Kinase; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000313903,0.0006867295,0.0007186304,0.0005969082,0.0004022666,0.0003542408,0.0005340694,0.0007317296,0.001370179],"category_scores_gemma":[0.0001535786,0.0002242002,0.0004723708,0.0003796436,0.0005945496,0.00052829,0.0002515096,0.001566414,0.0001904636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006294184,"about_ca_system_score_gemma":0.0006503716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001453069,"about_ca_topic_score_gemma":0.002389624,"domain_scores_codex":[0.9998003,0.00003556971,0.00002610563,0.00003723218,0.00003392137,0.0000668619],"domain_scores_gemma":[0.9998958,0.00000903953,0.00003497166,0.00001163384,0.000009362577,0.00003918427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01841343,0.002180273,0.0006827077,0.0002739198,0.0001062012,0.0007164031,0.00009465106,0.00144598,0.966229,0.001001828,0.0004761558,0.008379404],"study_design_scores_gemma":[0.002496323,0.01866759,0.00680449,0.00005079192,0.000351343,0.0005312428,0.0002219933,0.006137201,0.9609822,0.0007386992,0.002965932,0.00005214037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997376,0.0007386253,0.0006917633,0.0001899484,0.0001204376,0.00004918823,0.0002225929,0.00005357949,0.0005579828],"genre_scores_gemma":[0.9968601,0.0008238991,0.0007125443,0.00005108154,0.00002108963,0.00008222797,0.0002071047,0.000009068409,0.001232905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453069,"threshold_uncertainty_score":0.004583776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00798419195691511,"score_gpt":0.2399081446157746,"score_spread":0.2319239526588595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}