{"id":"W4390510299","doi":"10.3390/biom14010061","title":"Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes","year":2024,"lang":"en","type":"article","venue":"Biomolecules","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Canada Research Chairs; Canada First Research Excellence Fund; University of Toronto","keywords":"Connexin; Induced pluripotent stem cell; Gap junction; Cell biology; Casein kinase 2; Casein kinase 1; Kinase; Stem cell; Biology; Protein kinase C; Chemistry; Protein kinase A; Gene; Genetics; Mitogen-activated protein kinase kinase; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001649501,0.0003115872,0.000261959,0.0002295534,0.0001554177,0.00009307293,0.0001787877,0.0002078627,0.00007872409],"category_scores_gemma":[0.00001900457,0.0002755224,0.0002940437,0.0003369015,0.0002621393,0.000008364734,0.0001080085,0.0001487647,0.00004469795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008526655,"about_ca_system_score_gemma":0.000195296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007529709,"about_ca_topic_score_gemma":0.000476727,"domain_scores_codex":[0.9983466,0.0001685003,0.0003422319,0.0006245377,0.0001097727,0.0004083264],"domain_scores_gemma":[0.9993199,0.00003468867,0.00006257738,0.0003642878,0.0000836553,0.0001348894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005727304,0.0001020522,0.0003475234,0.00003799043,0.0001333799,0.0001989781,0.0001896826,0.00008622538,0.9936942,0.0007292107,0.001080126,0.003343394],"study_design_scores_gemma":[0.001098027,0.0008090366,0.006278222,0.00005742798,0.00009860287,0.0001161275,0.001305304,0.0003784897,0.9546462,0.0002065549,0.03439362,0.0006123603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986685,0.009736586,0.001290752,0.0003605342,0.0003911596,0.0003418901,0.0002447739,0.0000623227,0.0008869889],"genre_scores_gemma":[0.9980422,0.0002170733,0.0001798894,0.00009886068,0.0002395123,0.0000921449,0.0004745178,0.00004556902,0.0006102631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03904794,"threshold_uncertainty_score":0.9999697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814465864987375,"score_gpt":0.2837744624010319,"score_spread":0.2656298037511581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}