{"id":"W4390510313","doi":"10.1038/s41467-023-44437-y","title":"CRISPR-Cas-based identification of a sialylated human milk oligosaccharides utilization cluster in the infant gut commensal Bacteroides dorei","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"DSM Nutritional Products; Ministry of Health, State of Israel; Azrieli Foundation; Israel Science Foundation","keywords":"Bacteroides; Biology; Bifidobacterium; Microbiome; Bacteroides thetaiotaomicron; CRISPR; Gut flora; Complementation; Microbiology; Gene; Immunology; Bacteria; Genetics; Phenotype; Lactobacillus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002839564,0.000409176,0.000465783,0.000294345,0.0002203297,0.0005216885,0.0003437382,0.0004397429,0.001386178],"category_scores_gemma":[0.0003663184,0.0001853195,0.0003580502,0.0002115844,0.0003187511,0.0001302306,0.0005369618,0.0006828539,0.0005122073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003537049,"about_ca_system_score_gemma":0.0004074513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001935963,"about_ca_topic_score_gemma":0.002676075,"domain_scores_codex":[0.9997163,0.00002632423,0.00002966953,0.00008342847,0.00009494975,0.00004921805],"domain_scores_gemma":[0.99985,0.0000396799,0.00004310956,0.00001857664,0.0000158659,0.00003265356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001980416,0.00003318274,0.001089007,0.0001000479,0.00001299656,0.0002119061,0.00007516455,0.000457301,0.9910828,0.000336296,0.0003256239,0.006077614],"study_design_scores_gemma":[0.00006811655,0.0004692733,0.02059552,0.0000550667,0.00008447124,0.000926208,0.0003558268,0.01690579,0.9388233,0.000315369,0.02133432,0.00006671649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569543,0.001307505,0.03072681,0.0003963557,0.0001538874,0.0001935698,0.003597355,0.00154961,0.005120536],"genre_scores_gemma":[0.964614,0.0006679757,0.02586592,0.0002529057,0.00001125366,0.0001292614,0.003217949,0.0001614706,0.005079179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001935963,"threshold_uncertainty_score":0.004637182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05535089369892587,"score_gpt":0.3979932622665465,"score_spread":0.3426423685676206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}