{"id":"W4390510858","doi":"10.1302/1358-992x.2024.1.034","title":"MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLE MIMETICS AS OSTEOINDUCTIVE MEDIATORS: AN IN VITRO INVESTIGATION","year":2024,"lang":"en","type":"article","venue":"Orthopaedic Proceedings","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Mesenchymal stem cell; Nanomedicine; Microvesicles; In vitro; Vesicle; Chemistry; Exosome; Tissue engineering; Regenerative medicine; Stem cell; Cell biology; Cell; Biomedical engineering; Membrane; Nanotechnology; Biology; Biochemistry; Materials science; Nanoparticle; microRNA; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006106559,0.0003520399,0.0002284302,0.0002085562,0.00009285251,0.0001609725,0.0003506755,0.00033471,0.00002946073],"category_scores_gemma":[0.0001124418,0.0003694034,0.0001476934,0.0004884233,0.0002343346,0.00007765734,0.0001594063,0.0003593182,0.00007255819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009014889,"about_ca_system_score_gemma":0.0003291319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001766494,"about_ca_topic_score_gemma":0.000004508232,"domain_scores_codex":[0.9975963,0.00005821923,0.00046476,0.0009379283,0.0004335073,0.0005092912],"domain_scores_gemma":[0.9990209,0.00002169349,0.0001217989,0.0002805997,0.0001492879,0.0004057601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001461374,0.0001010924,0.002141114,0.0001745899,0.00002829875,0.0000864088,0.001092842,0.0000037496,0.9907081,0.0003923324,0.0003827317,0.004742607],"study_design_scores_gemma":[0.0006116052,0.0003092245,0.0005283518,0.00007646627,0.00006232371,0.00005181352,0.001985658,0.0007427398,0.9905921,0.0006248102,0.003971559,0.0004433752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990152,0.007245176,0.0001323872,0.0002494495,0.0003355462,0.0004476425,0.00002090592,0.0001197459,0.00129715],"genre_scores_gemma":[0.9965558,0.0001395326,0.001315227,0.0001445802,0.0006411031,0.00009092717,0.0001770339,0.00009783087,0.000837936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007105644,"threshold_uncertainty_score":0.9998758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009043490009096562,"score_gpt":0.2362513672182716,"score_spread":0.227207877209175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}