{"id":"W4390510858","doi":"10.1302/1358-992x.2024.1.034","title":"MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLE MIMETICS AS OSTEOINDUCTIVE MEDIATORS: AN IN VITRO INVESTIGATION","year":2024,"lang":"en","type":"article","venue":"Orthopaedic Proceedings","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Mesenchymal stem cell; Nanomedicine; Microvesicles; In vitro; Vesicle; Chemistry; Exosome; Tissue engineering; Regenerative medicine; Stem cell; Cell biology; Cell; Biomedical engineering; Membrane; Nanotechnology; Biology; Biochemistry; Materials science; Nanoparticle; microRNA; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005095745,0.0003450003,0.0003150555,0.0002673663,0.0001619734,0.0003586491,0.0002071666,0.0003327467,0.0003379965],"category_scores_gemma":[0.0001865736,0.0001283718,0.0003976875,0.0002508216,0.0001733659,0.0003117352,0.0002277834,0.0003138348,0.0002217128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060094,"about_ca_system_score_gemma":0.0002073273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004590378,"about_ca_topic_score_gemma":0.0007674266,"domain_scores_codex":[0.9996829,0.00007988809,0.00003555549,0.0000351221,0.000128975,0.00003769762],"domain_scores_gemma":[0.9998705,0.0000403646,0.00003220784,0.00001089711,0.00003099025,0.00001504372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005481913,0.00007991257,0.0002173828,0.0001585966,0.000006398907,0.00008133754,0.000036503,0.0002254514,0.9967111,0.00009509992,0.00002261112,0.002310827],"study_design_scores_gemma":[0.00000502363,0.0006673451,0.000978276,0.0000110766,0.00003503434,0.0001124469,0.00003924678,0.0009639675,0.9947792,0.00003738634,0.002366285,0.000004898029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775701,0.01180329,0.007700392,0.0001245623,0.00004759463,0.0001283482,0.0002771764,0.00003164849,0.002316901],"genre_scores_gemma":[0.981187,0.009492031,0.007046378,0.00007342221,0.00003624711,0.00009330069,0.0003707809,0.00001161484,0.001689284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005095745,"threshold_uncertainty_score":0.002694905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009043490009096562,"score_gpt":0.2362513672182716,"score_spread":0.227207877209175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}