{"id":"W4390511959","doi":"10.1038/s44318-023-00016-x","title":"Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression","year":2024,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Terry Fox Research Institute; Canada Research Chairs; Government of Ontario; Canadian Cancer Society; Ontario Institute for Cancer Research; Sontag Foundation","keywords":"Biology; Cancer; Glioblastoma; Aggression; Signature (topology); Computational biology; Cancer research; Cell biology; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008017244,0.000167211,0.0002467005,0.0004872098,0.0001129916,0.0002571528,0.00006157845,0.0001255946,0.0006858041],"category_scores_gemma":[0.0001319798,0.00007603595,0.0001470502,0.0003681981,0.0001369484,0.0001018547,0.0001550829,0.0001326167,0.000158294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001856751,"about_ca_system_score_gemma":0.0001463418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006270658,"about_ca_topic_score_gemma":0.0009406601,"domain_scores_codex":[0.9999372,0.000004407172,0.000004550003,0.00001834274,0.00001655168,0.00001898599],"domain_scores_gemma":[0.9999037,0.0000100553,0.00004560662,0.000007258378,0.00001352795,0.00001982436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002732642,0.00001370962,0.02546368,0.00005390157,0.00002202326,0.0001578375,0.00004597656,0.000201645,0.9691983,0.0001279959,0.0001398113,0.004301837],"study_design_scores_gemma":[0.00001342415,0.0002613294,0.7928094,0.00001246512,0.0001119042,0.0014057,0.0001750151,0.004045923,0.1975402,0.0005055465,0.003102179,0.00001680843],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974037,0.0003801478,0.0007595788,0.00002680016,0.000002718906,0.000005657809,0.0008420654,0.00006114019,0.0005182133],"genre_scores_gemma":[0.9980056,0.0001933968,0.0004634243,0.00002463872,0.000003094108,0.000008786154,0.001009714,0.00001059875,0.0002807169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006858041,"threshold_uncertainty_score":0.002294242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046263089131217,"score_gpt":0.2566797400686637,"score_spread":0.2462171091773516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}