{"id":"W4390533810","doi":"10.1126/scitranslmed.ade2774","title":"Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML","year":2024,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Pfizer; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Astellas Pharma; Loxo Oncology; Ludwig Center at Harvard; National Institutes of Health; Edward P. Evans Foundation; Servier; Genentech; AstraZeneca","keywords":"Cohesin; DNA repair; Biology; RNA splicing; DNA damage; Cancer research; Mutant; Exon; Gene; Genetics; DNA; Chromatin; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001469333,0.00008636194,0.0001102093,0.0001802091,0.0001178208,0.00002142265,0.0001021043,0.00003689216,0.000009166196],"category_scores_gemma":[0.0001954522,0.00006540581,0.00001707768,0.0003476088,0.0008643577,0.00001857879,0.00002938723,0.00008686465,4.021917e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008306783,"about_ca_system_score_gemma":0.0002122951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003801309,"about_ca_topic_score_gemma":0.000008344673,"domain_scores_codex":[0.9989225,0.0000374679,0.0001734259,0.0003085007,0.0003646573,0.0001934458],"domain_scores_gemma":[0.9995515,0.00009634311,0.00002213041,0.0001177334,0.00007246799,0.0001397746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001113543,0.000004865654,0.002539069,0.00003859813,0.000008028586,0.000005353253,0.0003271817,0.00003657378,0.992649,0.0004801175,0.000008492235,0.00379137],"study_design_scores_gemma":[0.0009805402,0.0009232581,0.1983952,0.0005612848,0.00002989446,0.0001011634,0.0006564399,0.03977458,0.7563542,0.001115771,0.0008512725,0.0002564291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944465,0.001878131,0.001551012,0.001840272,0.00006561633,0.000104457,0.000007535012,0.000008105211,0.00009840763],"genre_scores_gemma":[0.9992079,0.0001322093,0.0004239764,0.00006015417,0.00008491412,0.000002311084,0.000006067281,0.000007126256,0.00007538964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2362949,"threshold_uncertainty_score":0.3184762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545510715959593,"score_gpt":0.3124647635177501,"score_spread":0.2970096563581542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}