{"id":"W4390534938","doi":"10.21203/rs.3.rs-2596269/v2","title":"HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralization by antibodies","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs; Universiteit Antwerpen; Canada Excellence Research Chairs, Government of Canada","keywords":"Neutralization; Infectivity; Glycan; Lectin; Antibody; Virology; Human immunodeficiency virus (HIV); Virus; Glycoprotein; Biology; Chemistry; Immunology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939145,0.0003046322,0.0002632549,0.0002496421,0.0002012283,0.000545549,0.0002906288,0.00048039,0.002874169],"category_scores_gemma":[0.0002776778,0.0001872944,0.0003384266,0.0001432324,0.0002056491,0.000205028,0.0002739841,0.0006901047,0.0006278184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003706102,"about_ca_system_score_gemma":0.000172526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007485464,"about_ca_topic_score_gemma":0.0006217939,"domain_scores_codex":[0.9997717,0.00004899387,0.000007266714,0.00002329153,0.00004374164,0.000105021],"domain_scores_gemma":[0.9998806,0.00005317485,0.00001097133,0.00001305978,0.00001228247,0.00002992512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001772207,0.00006192767,0.0001752939,0.00001292909,0.00000595076,0.00003148378,0.00001005116,0.00006653012,0.9984718,0.0001392182,0.00007393191,0.0007736796],"study_design_scores_gemma":[0.00002094863,0.0002728983,0.004610292,0.000003898786,0.00001679333,0.0001768076,0.00002358642,0.001681089,0.9917876,0.0001052175,0.001295106,0.000005766204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949589,0.00072289,0.0008488505,0.0000961074,0.00003982415,0.0000133335,0.00006872156,0.00003392338,0.003217486],"genre_scores_gemma":[0.9950119,0.0002525511,0.0007850616,0.00008215023,0.00002278377,0.000007687736,0.0001793871,0.00001810676,0.003640414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002874169,"threshold_uncertainty_score":0.009615064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03361139212614795,"score_gpt":0.3624918539843829,"score_spread":0.3288804618582349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}