{"id":"W4390535948","doi":"10.1158/1078-0432.ccr-23-3275","title":"Transverse Colon Primary Tumor Location as a Biomarker in Metastatic Colorectal Cancer: A Pooled Analysis of CCTG/AGITG CO.17 and CO.20 Randomized Clinical Trials","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Hospital; Canadian Cancer Society; Queen's University; Spinal Cord Injury BC; University of British Columbia; University of British Columbia Hospital","funders":"Daiichi Sankyo Europe; Ipsen; Astellas Pharma; Eisai; Celgene; Bristol-Myers Squibb; AstraZeneca; Amgen; Pfizer; Genentech; Coherus Biosciences; Agios Pharmaceuticals; Michael Smith Health Research BC; Canadian Cancer Society; GlaxoSmithKline","keywords":"Cetuximab; Colorectal cancer; Medicine; KRAS; Internal medicine; Oncology; Transverse colon; Oxaliplatin; Randomized controlled trial; Confidence interval; Cancer; Gastroenterology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0140199,0.001568185,0.007626899,0.001332887,0.0002737715,0.001637024,0.000564332,0.001302524,0.001402548],"category_scores_gemma":[0.01435095,0.0006750582,0.01158689,0.001937643,0.0005544167,0.0006725024,0.0007535492,0.001064938,0.0001463509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008818477,"about_ca_system_score_gemma":0.000949252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002024425,"about_ca_topic_score_gemma":0.004199754,"domain_scores_codex":[0.9880398,0.008620781,0.001107398,0.001149609,0.0007084326,0.000373923],"domain_scores_gemma":[0.9858338,0.007168544,0.004854051,0.0008747035,0.0007603144,0.0005085249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.4546462,0.0002041869,0.04866091,0.01131401,0.4630334,0.0001598873,0.00006716834,0.001688576,0.00178742,0.0001428027,0.001637375,0.01665814],"study_design_scores_gemma":[0.1151122,0.01750441,0.10668,0.001473431,0.7526205,0.0002867648,0.00009220743,0.002459147,0.0009323835,0.0004356426,0.002310901,0.0000924687],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6623797,0.3276545,0.00201808,0.0006402202,0.0005902062,0.001172289,0.00360941,0.00009455378,0.001841076],"genre_scores_gemma":[0.984659,0.01137379,0.0008872246,0.0003708158,0.0003041928,0.000708934,0.00135221,0.00002119085,0.0003226257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0140199,"threshold_uncertainty_score":0.07414514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2936647154532566,"score_gpt":0.5987890595446822,"score_spread":0.3051243440914256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}