{"id":"W4390538085","doi":"10.3390/curroncol31010018","title":"Genetic Polymorphisms and Tumoral Mutational Profiles over Survival in Advanced Colorectal Cancer Patients: An Exploratory Study","year":2024,"lang":"en","type":"article","venue":"Current Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Comisión Nacional de Investigación Científica y Tecnológica; National Cancer Institute; Agencia Nacional de Investigación y Desarrollo; Universidad de Chile","keywords":"KRAS; Medicine; FOLFOX; Neuroblastoma RAS viral oncogene homolog; Oncology; DPYD; Colorectal cancer; Internal medicine; Chemotherapy; Oncogene; Cancer; Methylenetetrahydrofolate reductase; Cancer research; Genotype; Bioinformatics; Genetics; Pharmacogenetics; Biology; Oxaliplatin; Gene; Cell cycle","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688701,0.0001858024,0.0002643109,0.0005759444,0.0003675859,0.0003474811,0.0001580539,0.0002701395,0.001727087],"category_scores_gemma":[0.000662052,0.0001438566,0.0003553669,0.0006538529,0.0001774649,0.0001927829,0.0003720706,0.0002980454,0.0002405619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002962033,"about_ca_system_score_gemma":0.0003268344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003093728,"about_ca_topic_score_gemma":0.002613284,"domain_scores_codex":[0.9998686,0.00002944391,0.00001096742,0.00004042759,0.00001688152,0.00003354017],"domain_scores_gemma":[0.9996938,0.00006608075,0.00009021725,0.00003475367,0.0000374978,0.00007770682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000428637,0.0001231851,0.9972125,0.00001480067,0.00005175566,0.00016569,0.0001098962,0.00004765759,0.0004279414,0.00001734987,0.00006688904,0.001333719],"study_design_scores_gemma":[0.00002504944,0.0004485016,0.9981171,0.000005825993,0.00005102484,0.0003532274,0.0003417271,0.000158154,0.00007724811,0.00002690949,0.0003909481,0.000004291044],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995027,0.00007029756,0.00003171416,0.000009562341,0.000001074222,0.00001089412,0.0002000266,9.208892e-7,0.0001729141],"genre_scores_gemma":[0.9993929,0.00005449426,0.00004980671,0.00001282051,0.0000054429,0.00001714589,0.0002634606,0.000001200144,0.0002027677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003093728,"threshold_uncertainty_score":0.006151438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05562108136781068,"score_gpt":0.3932211838792334,"score_spread":0.3376001025114228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}