{"id":"W4390539469","doi":"10.3390/cancers16010224","title":"Transforming Growth Factor-β/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"SMAD; Cancer research; Melanoma; Metastasis; Cancer stem cell; Carcinogenesis; Signal transduction; Transforming growth factor; Stem cell; Cancer; Biology; Cell growth; R-SMAD; Transforming growth factor beta; Medicine; Cell biology; Endoglin; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000110314,0.0002505603,0.0002123453,0.0002540195,0.0001083894,0.0001886418,0.0001208474,0.0001479526,0.00134867],"category_scores_gemma":[0.0000583693,0.00009042583,0.0002052351,0.00009587696,0.0001431172,0.00009352768,0.0001023354,0.0005349187,0.0002113559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001456045,"about_ca_system_score_gemma":0.0002920854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006171836,"about_ca_topic_score_gemma":0.0016218,"domain_scores_codex":[0.9999127,0.00001521154,0.000007205998,0.000009940552,0.00002970438,0.00002526661],"domain_scores_gemma":[0.9999542,0.000007171811,0.00001048007,0.000004626854,0.00000476081,0.00001869405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001284189,0.00006458953,0.0001550947,0.0000334109,0.000006257543,0.00002443739,0.000007982427,0.00008498551,0.9968749,0.000125631,0.0000923375,0.00240183],"study_design_scores_gemma":[0.00002609483,0.0003874218,0.001595174,0.000005635529,0.00001471126,0.0001109745,0.00002010881,0.001233347,0.9934646,0.00006125789,0.003078659,0.00000201783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913846,0.002395704,0.002536261,0.0002164619,0.00006013383,0.000031104,0.0002528577,0.0001509822,0.002971811],"genre_scores_gemma":[0.9950297,0.001061061,0.001031227,0.00004973257,0.000008351813,0.00001788831,0.0002112738,0.00001303841,0.002577721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00134867,"threshold_uncertainty_score":0.004511774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252168895135568,"score_gpt":0.2618673560548938,"score_spread":0.2393456671035381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}