{"id":"W4390539469","doi":"10.3390/cancers16010224","title":"Transforming Growth Factor-β/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"SMAD; Cancer research; Melanoma; Metastasis; Cancer stem cell; Carcinogenesis; Signal transduction; Transforming growth factor; Stem cell; Cancer; Biology; Cell growth; R-SMAD; Transforming growth factor beta; Medicine; Cell biology; Endoglin; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556856,0.0002726655,0.0004048556,0.0002168996,0.0001153924,0.00009687092,0.00006354405,0.00006804537,0.0002316235],"category_scores_gemma":[0.000003169431,0.0002331982,0.0001607329,0.0004022995,0.00005352386,0.0003910216,0.00002023391,0.0002240739,0.00001217025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001414284,"about_ca_system_score_gemma":0.0008051948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046979,"about_ca_topic_score_gemma":0.0002602176,"domain_scores_codex":[0.9985047,0.00002904171,0.0003582934,0.0004033246,0.0003136127,0.0003910231],"domain_scores_gemma":[0.9993879,0.00004880041,0.00007477067,0.0001440468,0.0000882661,0.0002562488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005034341,0.00006768284,0.001227385,0.01450549,0.001340405,0.0003446506,0.02291118,0.0004250119,0.5461099,0.0006010782,0.004632942,0.4073308],"study_design_scores_gemma":[0.001247095,0.0002068455,0.00003344448,0.0007506582,0.0008965045,0.00007803815,0.001364939,0.0008663938,0.9325209,0.00003911945,0.0616373,0.0003588023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585625,0.03653412,0.0009708431,0.0003684885,0.0007682799,0.0005996925,0.0002247599,0.0002332721,0.001738068],"genre_scores_gemma":[0.9938875,0.004373419,0.0004902473,0.0003590557,0.0002844347,0.0001236748,0.00002091943,0.00005691045,0.000403872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.406972,"threshold_uncertainty_score":0.9509546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252168895135568,"score_gpt":0.2618673560548938,"score_spread":0.2393456671035381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}