{"id":"W4390545579","doi":"10.1002/pros.24661","title":"Transcriptomic analysis of benign prostatic hyperplasia identifies critical pathways in prostatic overgrowth and 5‐alpha reductase inhibitor resistance","year":2024,"lang":"en","type":"article","venue":"The Prostate","topic":"Urinary Bladder and Prostate Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Dutasteride; Finasteride; Medicine; Hyperplasia; Prostate; Urology; Internal medicine; 5 Alpha-Reductase Inhibitor; Benign prostatic hyperplasia (BPH); Combination therapy; Prostate cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195831,0.0002073886,0.0003569113,0.0004914236,0.0002606502,0.0004124105,0.0001238184,0.0001682449,0.001301642],"category_scores_gemma":[0.00023544,0.0001011853,0.0003597226,0.0005607297,0.0001882668,0.0001079615,0.0002106566,0.0002287264,0.0001621191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092916,"about_ca_system_score_gemma":0.0002395685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004096661,"about_ca_topic_score_gemma":0.0008171728,"domain_scores_codex":[0.9998128,0.00003245452,0.00001093268,0.00004720772,0.00005794307,0.00003864522],"domain_scores_gemma":[0.9998426,0.00003048934,0.00006479084,0.000008466294,0.00002292508,0.00003071118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00655928,0.0002350395,0.1327404,0.000562171,0.0003186314,0.0002984029,0.000209243,0.0007714022,0.8225126,0.0002309408,0.0007032729,0.03485863],"study_design_scores_gemma":[0.0001682428,0.001444827,0.9320958,0.00004828036,0.0003625035,0.0008122819,0.0003933427,0.002606316,0.05760739,0.0004789356,0.003961548,0.00002052504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934911,0.002743292,0.0009172652,0.0001244244,0.00001788857,0.00004713277,0.001923785,0.00002340855,0.0007116412],"genre_scores_gemma":[0.9932165,0.001171487,0.001554714,0.0001470529,0.00002370737,0.00009856279,0.003154045,0.000009563092,0.0006244787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301642,"threshold_uncertainty_score":0.004354417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091413648589339,"score_gpt":0.3145500660770899,"score_spread":0.2936359295911964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}