{"id":"W4390546062","doi":"10.1021/acs.jmedchem.3c00973","title":"Design, Synthesis, and Evaluation of New 1<i>H</i>-Benzo[<i>d</i>]imidazole Based PqsR Inhibitors as Adjuvant Therapy for <i>Pseudomonas aeruginosa</i> Infections","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Ministerio de Universidades; National Biofilms Innovation Centre; Biotechnology and Biological Sciences Research Council; Medical Research Council; University of Nottingham; Wellcome Trust","keywords":"Pseudomonas aeruginosa; Pyocyanin; Quorum sensing; Chemistry; Virulence; Microbiology; Biofilm; Adjuvant; Bacteria; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618535,0.0004283007,0.0004716051,0.0002316782,0.0001730436,0.0003253744,0.0005030737,0.0003396758,0.001310569],"category_scores_gemma":[0.0001207285,0.000176166,0.0002917097,0.0002301786,0.0001516058,0.0002765215,0.0001775761,0.0004235382,0.0005770018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000378994,"about_ca_system_score_gemma":0.0003310927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005432503,"about_ca_topic_score_gemma":0.00126888,"domain_scores_codex":[0.9999247,0.00001094406,0.000008210205,0.00001656523,0.00001674875,0.00002276979],"domain_scores_gemma":[0.9999545,0.000003475777,0.00001249517,0.000003164405,0.00001153514,0.000014788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002620244,0.0001876368,0.0001107733,0.0003503924,0.00001670573,0.0001275532,0.00003863861,0.001123482,0.9876074,0.0005170948,0.0004242357,0.009233996],"study_design_scores_gemma":[0.0001979063,0.002983306,0.001000647,0.00003617458,0.00005962462,0.0003394723,0.00003250557,0.002153723,0.9786569,0.000134591,0.01437209,0.00003298829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9208549,0.02152128,0.04034401,0.0008049018,0.0002088253,0.001184041,0.002667171,0.0007486721,0.01166618],"genre_scores_gemma":[0.9578221,0.01197344,0.0217432,0.0003229978,0.00004124242,0.0003570576,0.001514241,0.00005154153,0.006174178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310569,"threshold_uncertainty_score":0.004384279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282268651593405,"score_gpt":0.2892110595490459,"score_spread":0.2663883730331118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}