{"id":"W4390548166","doi":"10.1128/mbio.02291-23","title":"Sugar-binding and split domain combinations in repeats-in-toxin adhesins from <i>Vibrio cholerae</i> and <i>Aeromonas veronii</i> mediate cell-surface recognition and hemolytic activities","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Division of Materials Research; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Queen's University; National Science Foundation; National Institutes of Health; Government of Canada; Empire State Development Corporation","keywords":"Bacterial adhesin; Vibrio cholerae; Microbiology; Biology; Toxin; Human pathogen; Virulence; Bacteria; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191137,0.0002776638,0.0001835147,0.0001843189,0.000157255,0.0002001203,0.0002996923,0.0002230428,0.001764096],"category_scores_gemma":[0.0001712473,0.0001293426,0.0002693266,0.0001900167,0.000226123,0.0001886857,0.0002949951,0.0004342402,0.0003541304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002341841,"about_ca_system_score_gemma":0.0001717816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006059417,"about_ca_topic_score_gemma":0.0009409591,"domain_scores_codex":[0.9998651,0.00002981709,0.00001051974,0.00001583601,0.00004354643,0.00003527755],"domain_scores_gemma":[0.9999275,0.00001075184,0.00001859015,0.000009206276,0.000009513674,0.00002434244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003643945,0.00007406746,0.0007052787,0.00002608611,0.00001758507,0.0001518424,0.00001622543,0.0001490486,0.9965613,0.0002581907,0.00005811282,0.001617911],"study_design_scores_gemma":[0.00005672536,0.0007086733,0.007956977,0.000007693543,0.00005114997,0.0008241091,0.000058512,0.001292391,0.9859324,0.000131164,0.002969619,0.00001064488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973176,0.0003316908,0.001045553,0.00003290234,0.00001612456,0.00001614713,0.0001026608,0.00001087181,0.001126384],"genre_scores_gemma":[0.9963506,0.0001520775,0.001686051,0.00003860966,0.000004538083,0.00001197373,0.0003514761,0.000009299676,0.00139526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764096,"threshold_uncertainty_score":0.005901456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412190995200075,"score_gpt":0.2430208804979946,"score_spread":0.2288989705459939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}