{"id":"W4390548166","doi":"10.1128/mbio.02291-23","title":"Sugar-binding and split domain combinations in repeats-in-toxin adhesins from <i>Vibrio cholerae</i> and <i>Aeromonas veronii</i> mediate cell-surface recognition and hemolytic activities","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Division of Materials Research; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Queen's University; National Science Foundation; National Institutes of Health; Government of Canada; Empire State Development Corporation","keywords":"Bacterial adhesin; Vibrio cholerae; Microbiology; Biology; Toxin; Human pathogen; Virulence; Bacteria; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002596535,0.0001802647,0.0002032231,0.00008195934,0.00008862776,0.0001551763,0.00006110015,0.0001278878,0.000006756466],"category_scores_gemma":[0.00004801156,0.0001864726,0.00002555995,0.0001194682,0.0001734157,0.00002861081,0.0002107871,0.0001781218,0.000005352876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005102669,"about_ca_system_score_gemma":0.0000499437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002389498,"about_ca_topic_score_gemma":0.0006966757,"domain_scores_codex":[0.9987985,0.00009742154,0.0001943112,0.000501497,0.000120544,0.00028773],"domain_scores_gemma":[0.9996208,0.00009987617,0.00003312826,0.0001495595,0.00001706898,0.00007954845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005914794,0.000057345,0.005299966,0.0001037556,0.00003367251,0.00004124827,0.0008243823,8.078644e-7,0.991941,0.00001188469,0.0002273803,0.001399436],"study_design_scores_gemma":[0.004167245,0.000488127,0.04848082,0.0005348742,0.00005095654,0.00004575482,0.001815583,0.0002163551,0.9365909,0.002159575,0.004694018,0.0007558642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931628,0.005268522,0.00001177184,0.0005914951,0.0000896479,0.0002382937,0.0002233692,0.00001810909,0.0003959769],"genre_scores_gemma":[0.9950023,0.003970123,0.0003938298,0.00006066365,0.00005141478,0.00002429891,0.0002218281,0.00002463629,0.0002508883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05535014,"threshold_uncertainty_score":0.7604132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412190995200075,"score_gpt":0.2430208804979946,"score_spread":0.2288989705459939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}