{"id":"W4390562724","doi":"10.20944/preprints202401.0079.v1","title":"NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"","keywords":"Autophagy; KEAP1; Carcinogenesis; Signal transduction; Unfolded protein response; Cancer; Cancer research; Endoplasmic reticulum; Biology; Bioinformatics; Transcription factor; Medicine; Cell biology; Biochemistry; Internal medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005085908,0.0005263764,0.0006892406,0.0002001507,0.00005195057,0.00002194177,0.0002958788,0.0004007783,0.00007437632],"category_scores_gemma":[0.0005516633,0.0005047525,0.000209887,0.0001229204,0.0001808711,0.000004587922,0.00295658,0.0007330638,0.00004599321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112435,"about_ca_system_score_gemma":0.0002421924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002810272,"about_ca_topic_score_gemma":0.0001655601,"domain_scores_codex":[0.9967647,0.00021767,0.0007301569,0.001506834,0.000321338,0.0004593275],"domain_scores_gemma":[0.9982244,0.00006306595,0.0003869692,0.0009902696,0.0001646213,0.0001706433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004758341,0.0002858939,0.03294112,0.0003973715,0.0002102129,0.00008301731,0.0008400828,0.0002643479,0.9622165,0.00001982795,0.00002120007,0.002244569],"study_design_scores_gemma":[0.000478767,0.00009941198,0.07519092,0.000350736,0.00005402575,0.00002303196,0.0005373782,0.0001874035,0.9215971,0.0004695641,0.0005353203,0.0004763903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954854,0.001975725,0.000009496564,0.0001429205,0.0002901978,0.0006754883,0.0003998795,0.00003395256,0.0009869109],"genre_scores_gemma":[0.9979532,0.001219805,0.0001359186,0.0001161863,0.000129327,0.00009394681,0.0001889355,0.00006976806,0.00009294603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0422498,"threshold_uncertainty_score":0.9997404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02777621012563398,"score_gpt":0.2937656615099987,"score_spread":0.2659894513843648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}