{"id":"W4390571517","doi":"10.1186/s13024-023-00687-4","title":"Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Fleni; IXICO; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Servier; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Vetenskapsrådet; Eisai; European Federation of Pharmaceutical Industries and Associations; Vanderbilt University; EU Joint Programme – Neurodegenerative Disease Research; Vanderbilt University Medical Center; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; European Commission; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; Centene Corporation; Hope Center for Neurological Disorders; University of Southern California; Vanderbilt Memory and Alzheimer's Center; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Association","keywords":"TREM2; Neurology; Cerebrospinal fluid; Disease; Medicine; Neuroscience; Genomics; Human physiology; Alzheimer's disease; Molecular medicine; Bioinformatics; Computational biology; Biology; Pathology; Internal medicine; Receptor; Genetics; Gene; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842097,0.0003674295,0.0002405055,0.0004830426,0.0001647917,0.0002273596,0.0001297927,0.0002751676,0.001449182],"category_scores_gemma":[0.0001279413,0.0001172061,0.0003651487,0.0002205317,0.0001345341,0.0001004512,0.0001924674,0.000266743,0.0002544973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481348,"about_ca_system_score_gemma":0.0001089777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003845759,"about_ca_topic_score_gemma":0.0005698951,"domain_scores_codex":[0.9999298,0.00001060418,0.00000673348,0.0000179832,0.00002112474,0.00001387041],"domain_scores_gemma":[0.9999373,0.000009252047,0.00002403135,0.000004810485,0.000009946912,0.00001468976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005119597,0.00005189144,0.007559865,0.0000989218,0.00007171249,0.0008251542,0.0000419749,0.0001362601,0.9842253,0.0001569093,0.000334749,0.005985432],"study_design_scores_gemma":[0.0002557601,0.001269493,0.3759288,0.0000722146,0.00037643,0.01170348,0.0002788682,0.007325747,0.5868593,0.001417707,0.01447217,0.00003997085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940124,0.002657686,0.001496227,0.0002168486,0.00004166639,0.00001443155,0.0009197035,0.00004768631,0.0005932855],"genre_scores_gemma":[0.9951373,0.0008304004,0.00196263,0.0001238324,0.0000369839,0.00001613819,0.000856508,0.00001145781,0.001024798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449182,"threshold_uncertainty_score":0.004847944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0399730055412432,"score_gpt":0.2680070139466774,"score_spread":0.2280340084054342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}