{"id":"W4390579404","doi":"10.1016/j.chembiol.2023.12.007","title":"Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system","year":2024,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; HORIZON EUROPE Framework Programme; National Institutes of Health; Innovative Medicines Initiative; Bundesministerium für Bildung und Forschung; University of Saskatchewan; Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Infektionsforschung; Agence Nationale de la Recherche; Texas Tech University","keywords":"Ethionamide; Mycobacterium tuberculosis; Virulence; Prodrug; Tuberculosis; Microbiology; Antimycobacterial; Secretion; Drug discovery; Biology; Chemistry; Medicine; Ethambutol; Pharmacology; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668297,0.0003503248,0.0002832488,0.0001690111,0.00008430651,0.0003311186,0.000259196,0.000318139,0.001381672],"category_scores_gemma":[0.0001190086,0.0001366005,0.0002358584,0.00009435035,0.0001337842,0.0002380076,0.000260343,0.0006412196,0.0002528905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228216,"about_ca_system_score_gemma":0.000159079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001750562,"about_ca_topic_score_gemma":0.0005048874,"domain_scores_codex":[0.9999466,0.000005763723,0.000002987872,0.000009206189,0.00001369716,0.00002175279],"domain_scores_gemma":[0.9999597,0.000005392892,0.00001129642,0.000002965863,0.000007959392,0.00001262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003607699,0.0001285461,0.0001607754,0.00009560568,0.00001630856,0.0001003072,0.00001609136,0.0004081162,0.985126,0.0002849708,0.0002325181,0.01306998],"study_design_scores_gemma":[0.0002174015,0.002242712,0.001443357,0.0000181325,0.00004439902,0.0003241798,0.00002239103,0.002136121,0.9839671,0.0001204808,0.009450236,0.00001344743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785382,0.00855657,0.007855294,0.0004315557,0.0001975932,0.0001442381,0.0003394706,0.0002152304,0.003721827],"genre_scores_gemma":[0.9870117,0.003544063,0.004373839,0.0001543807,0.00004031872,0.00004779626,0.0003361487,0.00001310471,0.004478619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381672,"threshold_uncertainty_score":0.004622102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863102551945797,"score_gpt":0.2921261848728395,"score_spread":0.2734951593533815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}