{"id":"W4390580164","doi":"10.1164/rccm.202312-2213so","title":"Meaningful Endpoints for Idiopathic Pulmonary Fibrosis (IPF) Clinical Trials: Emphasis on ‘Feels, Functions, Survives’. Report of a Collaborative Discussion in a Symposium with Direct Engagement from Representatives of Patients, Investigators, the National Institutes of Health, a Patient Advocacy Organization, and a Regulatory Agency","year":2024,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Weill Cornell Medical College; National Institutes of Health; Imperial College London; Université de Lille; York University; McMaster University","keywords":"Medicine; Clinical trial; Clinical endpoint; Idiopathic pulmonary fibrosis; Intensive care medicine; Surrogate endpoint; Pirfenidone; Internal medicine; Lung","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3538959,0.002030362,0.00229832,0.001867724,0.01553963,0.02081005,0.004940673,0.02089909,0.003809556],"category_scores_gemma":[0.2991674,0.001644809,0.003110877,0.001951225,0.01914595,0.01604001,0.03252104,0.05761673,0.001324209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01042461,"about_ca_system_score_gemma":0.0369825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00146826,"about_ca_topic_score_gemma":0.00280387,"domain_scores_codex":[0.6528114,0.2952386,0.01505514,0.007251799,0.0230373,0.006605663],"domain_scores_gemma":[0.5363067,0.3518467,0.0230697,0.01028183,0.04271869,0.03577632],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"qualitative","study_design_scores_codex":[0.0006913741,0.0005437038,0.00259647,0.005180277,0.0002621871,0.001478838,0.2473288,0.0006094548,0.006060942,0.03739735,0.5513706,0.14648],"study_design_scores_gemma":[0.0002567154,0.0005763361,0.00245447,0.005392855,0.0001392827,0.000805757,0.09644141,0.0007979676,0.001724942,0.03567988,0.8553538,0.0003766411],"study_design_candidate":"qualitative","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.009290937,0.01447819,0.01232446,0.926607,0.03173117,0.0009170062,0.0001356249,0.0001427609,0.004372946],"genre_scores_gemma":[0.2528532,0.02629729,0.06638405,0.5667411,0.06838277,0.006714167,0.0006826458,0.0009372212,0.0110076],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6461041,"threshold_uncertainty_score":0.7967614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04365620660192326,"score_gpt":0.3786269491799046,"score_spread":0.3349707425779814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}