{"id":"W4390586798","doi":"10.1161/circresaha.123.322993","title":"Directional Endothelial Communication by Polarized Extracellular Vesicle Release","year":2024,"lang":"en","type":"article","venue":"Circulation Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; St. Michael's Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Microvesicles; Chemistry; Biology; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001184087,0.0001209097,0.00008468921,0.0001298165,0.0002923476,0.000195923,0.0002958215,0.0001648351,0.0002583912],"category_scores_gemma":[0.0003344939,0.0001333555,0.0001035869,0.0003301205,0.0002140304,0.00002042939,0.0001351637,0.0003288006,0.000251383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008848806,"about_ca_system_score_gemma":0.0001945031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006406427,"about_ca_topic_score_gemma":0.000007897577,"domain_scores_codex":[0.997973,0.0004987925,0.0002396764,0.0004551918,0.0005155514,0.0003177999],"domain_scores_gemma":[0.998872,0.0001022569,0.00002938537,0.0006348438,0.0002031104,0.0001583833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006085902,0.00009723697,0.001060483,0.00003508303,0.00003879714,0.000008701699,0.00004044045,0.0001026512,0.9828959,0.001826797,0.01084813,0.002984905],"study_design_scores_gemma":[0.001186455,0.0001368152,0.004033744,0.00009814866,0.00003725461,0.00004470733,0.0001646679,0.02370213,0.6189919,0.004149849,0.3469179,0.000536424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9357148,0.04046552,0.01707815,0.0009717626,0.0002185507,0.0005272002,0.0001216736,0.0001194191,0.004782968],"genre_scores_gemma":[0.9933238,0.0002532625,0.0004040394,0.00003712822,0.0002698779,0.00006938457,0.0008047249,0.00004657211,0.004791214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.363904,"threshold_uncertainty_score":0.5438079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025701381295897,"score_gpt":0.3435273736151547,"score_spread":0.3132703598021957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}