{"id":"W4390586798","doi":"10.1161/circresaha.123.322993","title":"Directional Endothelial Communication by Polarized Extracellular Vesicle Release","year":2024,"lang":"en","type":"article","venue":"Circulation Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; St. Michael's Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Microvesicles; Chemistry; Biology; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731919,0.0002808639,0.0002048154,0.0001582212,0.000178974,0.000765402,0.0001970625,0.0002774862,0.00146999],"category_scores_gemma":[0.0002399349,0.0001367974,0.0003163117,0.00009968838,0.0001687499,0.0003632537,0.0004698294,0.000397732,0.0007379266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002358264,"about_ca_system_score_gemma":0.0001559705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001429807,"about_ca_topic_score_gemma":0.0001142192,"domain_scores_codex":[0.9998053,0.00003692219,0.000010787,0.00005080052,0.00004770852,0.00004852035],"domain_scores_gemma":[0.9998717,0.00003651037,0.00003361781,0.00001847047,0.00002711291,0.0000125437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001807533,0.0000245047,0.0005867226,0.0001307589,0.00001599834,0.0001976336,0.00003413821,0.0009204797,0.9865644,0.001998805,0.0004996532,0.008846103],"study_design_scores_gemma":[0.00004396968,0.0001464832,0.002673874,0.00003194567,0.00002981113,0.0003911821,0.00007539739,0.01718605,0.9671105,0.000950553,0.0113417,0.00001848923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9240848,0.003688737,0.06245458,0.0004285646,0.0002103284,0.00007895119,0.0009257146,0.000513221,0.007615251],"genre_scores_gemma":[0.9873081,0.001459982,0.007592622,0.0001190108,0.00002682459,0.00005937022,0.0005160991,0.00007726577,0.002840728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00146999,"threshold_uncertainty_score":0.004917622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025701381295897,"score_gpt":0.3435273736151547,"score_spread":0.3132703598021957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}