{"id":"W4390590900","doi":"10.1126/science.adh8342","title":"Microbiota-dependent activation of CD4 <sup>+</sup> T cells induces CTLA-4 blockade–associated colitis via Fcγ receptors","year":2024,"lang":"en","type":"article","venue":"Science","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; Crohn's and Colitis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Takeda Oncology; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Colitis; Blockade; Immune system; CTLA-4; Immunology; Immune checkpoint; Discontinuation; Inflammation; Antibody; Receptor; Cancer research; Immunity; Medicine; T cell; Immunotherapy; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514946,0.0004150008,0.0003045799,0.0002427195,0.0001389176,0.0003383603,0.0001587609,0.0002955181,0.001824808],"category_scores_gemma":[0.00010468,0.0001340996,0.000280593,0.0001086339,0.0002396599,0.0001680578,0.0002401579,0.001425866,0.0004358171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419568,"about_ca_system_score_gemma":0.0002640691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000216874,"about_ca_topic_score_gemma":0.0004461301,"domain_scores_codex":[0.9997681,0.00004333062,0.00001977058,0.00003593714,0.00004369349,0.00008917937],"domain_scores_gemma":[0.9998884,0.00001452207,0.00003097503,0.00001504503,0.000006815586,0.00004419442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004260622,0.0001921317,0.0001621822,0.00003449528,0.000006101531,0.00004575843,0.000008612173,0.00008103728,0.9967424,0.00008644895,0.0001060528,0.00210867],"study_design_scores_gemma":[0.00007955675,0.001630572,0.003320987,0.00001136122,0.00001550955,0.0002039335,0.00003606605,0.001256432,0.9914834,0.00009496522,0.00186321,0.000004065329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952638,0.000605133,0.001530843,0.0001849359,0.00007780241,0.00003910397,0.0001944898,0.0001337308,0.001970073],"genre_scores_gemma":[0.9947903,0.0003669122,0.001740449,0.0001525655,0.00003162786,0.00006169186,0.0002733429,0.00003131022,0.002551736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824808,"threshold_uncertainty_score":0.006104529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006854663548178,"score_gpt":0.2329988069370944,"score_spread":0.2229302603016126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}