{"id":"W4390639097","doi":"10.1177/17562864231221324","title":"Tenecteplase for the treatment of acute ischemic stroke in the extended time window: a systematic review and meta-analysis","year":2024,"lang":"en","type":"review","venue":"Therapeutic Advances in Neurological Disorders","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"Heart and Stroke Foundation of Canada","keywords":"Medicine; Modified Rankin Scale; Tenecteplase; Odds ratio; Meta-analysis; Thrombolysis; Randomized controlled trial; Confidence interval; Internal medicine; Stroke (engine); Fibrinolytic agent; Relative risk; Tissue plasminogen activator; Ischemic stroke; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000638516,0.0006837029,0.006478591,0.0002690238,0.00003872188,0.00001913951,0.0005230922,0.0001593973,0.00006729472],"category_scores_gemma":[0.00009148979,0.0002477666,0.002617116,0.001060507,0.0002570914,0.00004525651,0.00007424665,0.0003812102,0.00000850221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004149328,"about_ca_system_score_gemma":0.00003090727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002966371,"about_ca_topic_score_gemma":0.000007349784,"domain_scores_codex":[0.9967697,0.0005361084,0.001247534,0.0007291902,0.0003481691,0.0003693349],"domain_scores_gemma":[0.9959475,0.0025195,0.000495548,0.0009738695,0.00002274831,0.0000408225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001885955,0.0009914835,0.000006586848,0.6361086,0.2555629,0.00008712769,0.0001924092,0.00001302769,0.000001074114,0.0001182551,0.0002260082,0.1065039],"study_design_scores_gemma":[0.0003619472,0.0006866116,0.000002833908,0.002383418,0.7443034,0.00002879298,0.00002560531,0.0001148316,1.337582e-7,0.00006128211,0.251871,0.0001601008],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005876149,0.985873,0.0001416939,0.001894717,0.00002446554,0.01151282,0.000173235,0.00002789463,0.0003462603],"genre_scores_gemma":[0.0001413323,0.9905033,0.00009283976,0.001921552,0.00001205478,0.00660828,0.00005622954,0.00003997152,0.0006245143],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6337252,"threshold_uncertainty_score":0.9999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05182824086950986,"score_gpt":0.3710587875438052,"score_spread":0.3192305466742953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}