{"id":"W4390639402","doi":"10.1016/j.isci.2024.108813","title":"Antiviral response and HIV-1 inhibition in sickle cell disease","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institute of General Medical Sciences; Fogarty International Center; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Office of AIDS Research; National Institute on Aging; District of Columbia Developmental Center for AIDS Research; Center for AIDS Research, University of Washington; U.S. Food and Drug Administration; National Cancer Institute; National Institutes of Health","keywords":"Hemolysis; Downregulation and upregulation; Immunology; Hypoxia (environmental); Disease; Peripheral blood mononuclear cell; Interferon; Antiviral protein; Cell; Human immunodeficiency virus (HIV); Medicine; Virology; Gene; Biology; Chemistry; RNA; In vitro; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162741,0.0001217554,0.000132397,0.0001231907,0.00007990721,0.0001524895,0.00005899528,0.0001074425,0.00188383],"category_scores_gemma":[0.00007746591,0.00005310531,0.00006500733,0.00004894442,0.0000903374,0.00005333165,0.00008491819,0.0003504653,0.0001524864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008368232,"about_ca_system_score_gemma":0.00009546643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000131785,"about_ca_topic_score_gemma":0.0003128866,"domain_scores_codex":[0.9999394,0.00002024653,0.000004524061,0.000008425919,0.0000120572,0.00001527796],"domain_scores_gemma":[0.9999658,0.000008294058,0.000007083724,0.00000285621,0.000003474438,0.00001252862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005569209,0.00009888143,0.0005947992,0.00006559667,0.000008146561,0.000058204,0.000022,0.00005777838,0.9915767,0.0002107876,0.0002506683,0.006499489],"study_design_scores_gemma":[0.0001256122,0.002422588,0.02674939,0.0000337365,0.00003038294,0.0007815594,0.00006871254,0.000872664,0.9585868,0.0002086904,0.01011516,0.00000482829],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922761,0.00468718,0.0004772436,0.00009620294,0.00006507287,0.0000149697,0.0001913246,0.00003363515,0.002158249],"genre_scores_gemma":[0.9956168,0.0009754304,0.0006040111,0.00007328094,0.0000269039,0.00002266369,0.0002604539,0.000004090273,0.00241633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00188383,"threshold_uncertainty_score":0.006302059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006814261144019227,"score_gpt":0.2462623724641501,"score_spread":0.2394481113201308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}