{"id":"W4390639402","doi":"10.1016/j.isci.2024.108813","title":"Antiviral response and HIV-1 inhibition in sickle cell disease","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institute of General Medical Sciences; Fogarty International Center; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Office of AIDS Research; National Institute on Aging; District of Columbia Developmental Center for AIDS Research; Center for AIDS Research, University of Washington; U.S. Food and Drug Administration; National Cancer Institute; National Institutes of Health","keywords":"Hemolysis; Downregulation and upregulation; Immunology; Hypoxia (environmental); Disease; Peripheral blood mononuclear cell; Interferon; Antiviral protein; Cell; Human immunodeficiency virus (HIV); Medicine; Virology; Gene; Biology; Chemistry; RNA; In vitro; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002364357,0.00004999594,0.00005719469,0.000105534,0.00003515938,0.00002982669,0.00001645934,0.00002799619,0.00001968212],"category_scores_gemma":[0.00006097645,0.00003786613,0.00001791086,0.0003306196,0.0001409354,0.0001141661,0.00002467176,0.0001039798,0.00007762673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002141631,"about_ca_system_score_gemma":0.0001137753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006691709,"about_ca_topic_score_gemma":0.000001470048,"domain_scores_codex":[0.9994646,0.00002491615,0.00007711785,0.000186915,0.0001143951,0.0001320412],"domain_scores_gemma":[0.9997888,0.00003534833,0.000006631405,0.00007670943,0.000007652256,0.00008483869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0036288,0.0008795996,0.08270209,0.001361364,0.00001132113,0.01375119,0.01278137,0.0001708343,0.7923738,0.002436975,0.01450069,0.07540199],"study_design_scores_gemma":[0.00486432,0.00101988,0.8042729,0.003423718,0.0001288015,0.0002672403,0.004433407,0.07974828,0.03773332,0.002980677,0.06025624,0.0008712029],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901094,0.002899482,0.00007149253,0.003943772,0.00008840919,0.00010253,0.000005171678,0.00003934776,0.002740395],"genre_scores_gemma":[0.9978329,0.0001370735,0.00004998538,0.000244637,0.00001347173,0.000002911916,0.000002092225,0.000004455324,0.001712466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7546405,"threshold_uncertainty_score":0.1544136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006814261144019227,"score_gpt":0.2462623724641501,"score_spread":0.2394481113201308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}