{"id":"W4390645985","doi":"10.1097/hc9.0000000000000361","title":"Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases.","year":2024,"lang":"en","type":"article","venue":"PubMed","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; University of Colorado Denver; Ipsen; Astellas Pharma; Office of Dietary Supplements; National Institutes of Health; Rare Diseases Clinical Research Network; bluebird bio; Gilead Sciences; Sanofi; Cystic Fibrosis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Audentes Therapeutics","keywords":"GDF15; FGF21; Liver transplantation; Alagille syndrome; Internal medicine; Medicine; Biliary atresia; Biomarker; Gastroenterology; Liver disease; Mitochondrial disease; Endocrinology; Transplantation; Cholestasis; Fibroblast growth factor; Biology; Mitochondrial DNA; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001688145,0.0008180423,0.0004995517,0.001560374,0.0001842827,0.0006090637,0.0003566859,0.0007092468,0.0008869417],"category_scores_gemma":[0.003664565,0.0001979477,0.0004821939,0.0006510631,0.0003040951,0.0004649526,0.0003844082,0.0006758796,0.0003599408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005604524,"about_ca_system_score_gemma":0.0004933869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002126436,"about_ca_topic_score_gemma":0.002751418,"domain_scores_codex":[0.9993334,0.0001752535,0.00008998808,0.0001344719,0.0001956892,0.00007114761],"domain_scores_gemma":[0.9981914,0.0004793187,0.0007258482,0.00005639436,0.0002891206,0.0002578638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002691299,0.00003181365,0.9871954,0.00004294313,0.00008667581,0.0001478146,0.00003158468,0.0002609972,0.001448743,0.00004545771,0.0003412397,0.01009824],"study_design_scores_gemma":[0.00004719564,0.0005912143,0.9837874,0.00008012745,0.0001175247,0.004003537,0.00007843772,0.00378962,0.005417452,0.0001927812,0.001878053,0.00001670881],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870073,0.008632684,0.001877056,0.0002665433,0.00006212266,0.00006511647,0.0006034411,0.00009795868,0.001387688],"genre_scores_gemma":[0.9947221,0.0006947697,0.00358228,0.00008628557,0.00002066584,0.00004053923,0.0005437639,0.000008341319,0.0003013682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002126436,"threshold_uncertainty_score":0.008927882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102028726646713,"score_gpt":0.2052130260266335,"score_spread":0.1941927387601664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}