{"id":"W4390649677","doi":"10.1101/2024.01.04.574193","title":"Constraint on boric acid resistance and tolerance evolvability in <i>Candida albicans</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Plant Pathogens and Fungal Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research","keywords":"Candida albicans; Corpus albicans; Biology; Microbiology; Evolvability; Fluconazole; Drug resistance; Yeast; Resistance (ecology); Boric acid; Antifungal; Genetics; Chemistry; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004532887,0.0004059989,0.000472,0.0003053661,0.0004837967,0.001192638,0.0004941525,0.0005621269,0.00156935],"category_scores_gemma":[0.001158774,0.0001770204,0.0002978077,0.0002998667,0.0003780725,0.0003809649,0.000912905,0.0009318978,0.0002755514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000600173,"about_ca_system_score_gemma":0.0003145957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004074,"about_ca_topic_score_gemma":0.00121866,"domain_scores_codex":[0.9996614,0.00006842225,0.00003118875,0.00007762521,0.00009965534,0.00006171398],"domain_scores_gemma":[0.9995028,0.0001597665,0.00008694435,0.00008614706,0.00008763404,0.00007675168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002631709,0.00008658077,0.007762372,0.00008351841,0.00004176293,0.0002410018,0.0001214767,0.002997225,0.9784642,0.000660956,0.0002312741,0.009046439],"study_design_scores_gemma":[0.00008051805,0.001595429,0.1370396,0.0000997363,0.0001441153,0.002698509,0.0005947226,0.04748204,0.7955117,0.002398717,0.01216439,0.0001905256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956149,0.0002765254,0.001804693,0.0001122461,0.00001282766,0.00001344397,0.0003208212,0.00008504467,0.001759571],"genre_scores_gemma":[0.9955552,0.0001783614,0.002478883,0.00007718494,0.000006358668,0.00002108964,0.0006054241,0.00006501322,0.001012285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156935,"threshold_uncertainty_score":0.005250037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006845147779809327,"score_gpt":0.2057339545595485,"score_spread":0.1988888067797392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}