{"id":"W4390649747","doi":"10.1101/2024.01.03.574113","title":"A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Stanford Bio-X; National Institutes of Health","keywords":"Galectin; Cell biology; Endosome; Lysosome; Internalization; Galectin-1; Biology; Intracellular; Cytosol; CRISPR; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731612,0.0005714358,0.0004068546,0.000377787,0.0001964895,0.0006164713,0.0003281072,0.0007304888,0.001520971],"category_scores_gemma":[0.0002093559,0.0002057546,0.0003365985,0.0002813916,0.0002792799,0.0001085948,0.0004827296,0.000594951,0.0006891497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003504306,"about_ca_system_score_gemma":0.0002949166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077282,"about_ca_topic_score_gemma":0.00190785,"domain_scores_codex":[0.9998178,0.00001959396,0.00001195509,0.00005388542,0.00006472333,0.0000321281],"domain_scores_gemma":[0.9998875,0.00003644183,0.00002660926,0.00001232451,0.00001018405,0.00002705287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007086158,0.00001480065,0.0004341172,0.00003950199,0.00001546481,0.0002687181,0.00001352378,0.0003326571,0.9954431,0.0001633728,0.0002019812,0.003001998],"study_design_scores_gemma":[0.00003256259,0.0001844559,0.009701215,0.00001381043,0.0001041326,0.00129299,0.00004844414,0.005203473,0.9759054,0.0001592791,0.007331973,0.00002224819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566917,0.001379523,0.02740629,0.0004168022,0.0001005195,0.0001106643,0.004377481,0.00154929,0.007967797],"genre_scores_gemma":[0.9782599,0.0009757213,0.01106019,0.0002902294,0.000009206062,0.00005347493,0.002944844,0.0002129868,0.006193473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520971,"threshold_uncertainty_score":0.005088151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557970754145586,"score_gpt":0.2450171873482327,"score_spread":0.2294374798067769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}