{"id":"W4390649747","doi":"10.1101/2024.01.03.574113","title":"A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Stanford Bio-X; National Institutes of Health","keywords":"Galectin; Cell biology; Endosome; Lysosome; Internalization; Galectin-1; Biology; Intracellular; Cytosol; CRISPR; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001497023,0.0008120554,0.000906288,0.0004281082,0.000721867,0.0003215908,0.00116562,0.001394599,0.0004729437],"category_scores_gemma":[0.000811065,0.0006773902,0.0005543943,0.0005459367,0.0004945314,0.0000751716,0.001024174,0.001950402,0.0009821485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003022355,"about_ca_system_score_gemma":0.001695922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000183882,"about_ca_topic_score_gemma":0.00005725257,"domain_scores_codex":[0.9956335,0.0005324612,0.0009037147,0.001653633,0.0001234265,0.001153265],"domain_scores_gemma":[0.9968275,0.0005726333,0.0004999481,0.001469382,0.0005366658,0.0000939013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005695156,0.00009518146,0.0009623173,0.0003297499,0.0009696172,0.00001673955,0.00009225107,0.00002411617,0.9905048,0.0007760656,0.005649712,0.00000993601],"study_design_scores_gemma":[0.0009766722,0.0003376412,0.02795451,0.0004029947,0.0005653953,4.4279e-7,0.000061853,0.00001300699,0.8323799,0.00008063827,0.1361249,0.001102049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629969,0.02453179,0.000350547,0.001931789,0.006863187,0.001875029,0.00070059,0.0006962845,0.00005386811],"genre_scores_gemma":[0.9958305,0.0005635086,0.0004679199,0.0005730613,0.0007113766,0.001027576,0.000007144305,0.0002123105,0.0006065729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1581249,"threshold_uncertainty_score":0.9999018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557970754145586,"score_gpt":0.2450171873482327,"score_spread":0.2294374798067769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}