{"id":"W4390649787","doi":"10.1101/2024.01.04.574235","title":"Novel Pentafluorosulfanyl-containing Triclocarban Analogs selectively kill Gram-positive bacteria","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Agencia Estatal de Investigación; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; Instituto de Salud Carlos III; European Regional Development Fund; Generalitat de Catalunya; Centres de Recerca de Catalunya","keywords":"Triclocarban; Antibacterial activity; Ciprofloxacin; Microbiology; Staphylococcus aureus; Antibiotics; Minimum inhibitory concentration; Bacteria; Chemistry; Triclosan; Gram-positive bacteria; Minimum bactericidal concentration; Antibiotic resistance; Gram-negative bacteria; Escherichia coli; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007306772,0.0002881121,0.0001618181,0.0001014036,0.00006282111,0.0001263651,0.0001758306,0.0001937225,0.001215818],"category_scores_gemma":[0.0001196877,0.00006156183,0.0000983764,0.00009455977,0.0001127176,0.0001247316,0.0001013824,0.0002156899,0.0002700985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001148124,"about_ca_system_score_gemma":0.00008382624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002738326,"about_ca_topic_score_gemma":0.0003665782,"domain_scores_codex":[0.9999293,0.00001991788,0.00000586815,0.00001231017,0.00001844089,0.00001415091],"domain_scores_gemma":[0.9999359,0.00001148215,0.00001927911,0.000006208442,0.00001087295,0.00001630024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002397289,0.00003060592,0.00007817241,0.00007110039,0.000006164512,0.00005845982,0.0000113787,0.0001604281,0.9947825,0.00004550169,0.00006778342,0.004448076],"study_design_scores_gemma":[0.00004036943,0.001865697,0.001297208,0.00001004257,0.00001544347,0.0004386838,0.00001560868,0.0005596844,0.9927601,0.00001758332,0.002971717,0.000008029289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940509,0.002110955,0.001447145,0.00005209285,0.00002576993,0.00003306452,0.0001403263,0.00003090623,0.002108949],"genre_scores_gemma":[0.9933576,0.001126716,0.003550342,0.00009186038,0.00001157469,0.00003060513,0.000301712,0.00001277421,0.001516767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001215818,"threshold_uncertainty_score":0.004067302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111310148725403,"score_gpt":0.2110950276213559,"score_spread":0.1999819261341019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}