{"id":"W4390656864","doi":"10.1101/2024.01.03.574013","title":"Assessment of autophagy in <i>Leishmania</i> parasites","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; Leishmania; Biology; Leishmaniasis; Cell biology; Acridine orange; Organelle; ATG8; Sandfly; Intracellular parasite; Amastigote; Leishmania major; Cutaneous leishmaniasis; Phagosome; Microbiology; Parasite hosting; Intracellular; Immunology; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002292749,0.0002538878,0.0001491456,0.0003604146,0.0002510704,0.0002944581,0.0001165757,0.0002535716,0.001316734],"category_scores_gemma":[0.0001202085,0.0001004297,0.0001214544,0.000225015,0.0001717917,0.0002169681,0.000195312,0.0003788838,0.0005079565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940895,"about_ca_system_score_gemma":0.0001276137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006148762,"about_ca_topic_score_gemma":0.0006198493,"domain_scores_codex":[0.9999001,0.00002574355,0.00000936911,0.0000227579,0.00002189336,0.00001997949],"domain_scores_gemma":[0.9999087,0.0000189083,0.00001599802,0.000008186048,0.00003218107,0.00001611136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003959221,0.000008507003,0.0001805146,0.00002781707,0.000001915481,0.0000236571,0.00001415771,0.00002414124,0.9991562,0.00006673687,0.00004443121,0.0004124228],"study_design_scores_gemma":[0.000007652412,0.0001750007,0.006993564,0.00001689619,0.0000128224,0.0003454345,0.0000735384,0.0009067891,0.9880503,0.0000996723,0.003312414,0.000005888626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692084,0.002916596,0.01721772,0.0001611277,0.00006035457,0.0001167422,0.001493559,0.0003270424,0.008498589],"genre_scores_gemma":[0.9667594,0.002081778,0.0231255,0.0001349945,0.00002482656,0.0001159655,0.002174383,0.0001535271,0.005429787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316734,"threshold_uncertainty_score":0.004404902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167317557268225,"score_gpt":0.3025494874340308,"score_spread":0.2808763118613485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}