{"id":"W4390656914","doi":"10.1101/2024.01.01.573829","title":"Valine Catabolism Drives Bioenergetic and Lipogenic Fuel Plasticity in Prostate Cancer","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Downregulation and upregulation; Lipogenesis; Prostate cancer; Catabolism; Valine; Bioenergetics; Biology; LNCaP; Beta oxidation; Cancer research; Biochemistry; Chemistry; Mitochondrion; Endocrinology; Metabolism; Cancer; Amino acid; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687613,0.0002244934,0.0002549148,0.0002785441,0.0001793883,0.0006031656,0.0001329079,0.0002417493,0.001334191],"category_scores_gemma":[0.0001084609,0.0001574357,0.0002160446,0.0003110894,0.0002517145,0.0001516307,0.0003460645,0.0005245733,0.0003989489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003612329,"about_ca_system_score_gemma":0.0002698767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000780492,"about_ca_topic_score_gemma":0.0007573009,"domain_scores_codex":[0.999912,0.00001481015,0.000005190169,0.00002377398,0.00002271859,0.00002131848],"domain_scores_gemma":[0.9999287,0.00001105634,0.00001821295,0.000009587972,0.00001020337,0.00002210248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002429606,0.00001407838,0.001310345,0.00006166312,0.00001033929,0.00007629849,0.00001620393,0.0001886741,0.9952292,0.0002342857,0.000152573,0.002463374],"study_design_scores_gemma":[0.00002794985,0.000233303,0.02318181,0.00001327465,0.00003207832,0.0006929377,0.00007348272,0.002442036,0.9644148,0.0006312935,0.008244892,0.00001220651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821374,0.006545608,0.00647205,0.0005721063,0.00007997476,0.00002815067,0.001605757,0.0002578622,0.002301124],"genre_scores_gemma":[0.9933946,0.001652071,0.001790955,0.00009141616,0.00001477225,0.00001598449,0.001031754,0.00002967882,0.001978833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334191,"threshold_uncertainty_score":0.004463315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007594069244151193,"score_gpt":0.2273769861817617,"score_spread":0.2197829169376106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}