{"id":"W4390660365","doi":"10.21203/rs.3.rs-3717633/v1","title":"Structure and engineering of Brevibacillus laterosporus Cas9","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Japan Society for the Promotion of Science; Core Research for Evolutional Science and Technology; Japan Agency for Medical Research and Development","keywords":"Computer science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357303,0.000350603,0.0002893194,0.0001674082,0.0003219908,0.0005055984,0.0005259956,0.0004747805,0.0007973737],"category_scores_gemma":[0.0001949875,0.000216848,0.000226208,0.0002359168,0.0001919949,0.000157416,0.0001874736,0.000620132,0.0004028758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008104877,"about_ca_system_score_gemma":0.000438618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004053181,"about_ca_topic_score_gemma":0.003123466,"domain_scores_codex":[0.9998958,0.00001371193,0.000008683453,0.00002078482,0.00004771652,0.00001326614],"domain_scores_gemma":[0.9999185,0.000009673307,0.00002166029,0.00001008399,0.0000147029,0.00002542891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001899001,0.0001117685,0.0007360952,0.00008953836,0.00001874029,0.000464508,0.00005549493,0.00781089,0.9847484,0.001695841,0.0004232232,0.003655557],"study_design_scores_gemma":[0.00009556759,0.00017607,0.00201242,0.00001268117,0.00001871844,0.0003652409,0.00006694542,0.02840168,0.9566655,0.0004024812,0.01175635,0.00002633355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758517,0.000839072,0.01800459,0.000340778,0.0000859694,0.00009885059,0.001131379,0.0003460915,0.003301702],"genre_scores_gemma":[0.9694317,0.0005029573,0.02428422,0.0000368544,0.00000654846,0.00004249552,0.002156276,0.00005810642,0.003480693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004053181,"threshold_uncertainty_score":0.008059144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595802920062651,"score_gpt":0.3672311794056583,"score_spread":0.3512731502050318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}