{"id":"W4390663732","doi":"10.1038/s41467-023-44300-0","title":"Developmental basis of SHH medulloblastoma heterogeneity","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Institut National Du Cancer; Hospital for Sick Children; Government of Ontario; Deutsche Krebshilfe; Terry Fox Research Institute; Studienstiftung des Deutschen Volkes; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Brain Tumour Charity; Cancer Research UK; Stand Up To Cancer; Genome British Columbia; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; National Cancer Institute; University of Toronto; USC Norris Comprehensive Cancer Center; Genome Canada","keywords":"Sonic hedgehog; Medulloblastoma; Biology; PTCH1; Patched; Hedgehog; Carcinogenesis; Progenitor cell; Computational biology; Cancer research; Neuroscience; Gene; Stem cell; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009843353,0.00007067397,0.00006310549,0.00004320344,0.00008369368,0.00001711229,0.0005038184,0.0001610115,0.0000215723],"category_scores_gemma":[0.00003506166,0.00006640289,0.00006985207,0.0001621024,0.00009710738,0.000003634641,0.0001967859,0.0001853324,0.00001369341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000211488,"about_ca_system_score_gemma":0.0001228232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006954362,"about_ca_topic_score_gemma":0.0002320684,"domain_scores_codex":[0.999515,0.00003918988,0.0001392938,0.000150306,0.00007602187,0.00008016526],"domain_scores_gemma":[0.9992208,0.00001874668,0.00002765556,0.0006231149,0.00007809361,0.00003154972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000142378,0.0001199842,0.002795732,0.00003027443,0.0001860794,4.717071e-7,0.0001016118,0.000009953168,0.9436671,0.01099171,0.02117525,0.02090764],"study_design_scores_gemma":[0.00009077619,0.00003324198,0.01029193,0.00002732291,0.00002309815,0.00001577706,0.00007216823,0.0001708138,0.2968015,0.00006140556,0.6922853,0.0001266002],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9200289,0.0623542,0.001055708,0.002512401,0.0002273568,0.0002098405,0.0001576157,0.00004892944,0.01340502],"genre_scores_gemma":[0.990796,0.001633937,0.006881383,0.0001399096,0.00003851504,0.00004338596,0.0001625921,0.0000120832,0.0002922085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6711101,"threshold_uncertainty_score":0.2707831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780683974207817,"score_gpt":0.3107705891926665,"score_spread":0.2929637494505883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}