{"id":"W4390663732","doi":"10.1038/s41467-023-44300-0","title":"Developmental basis of SHH medulloblastoma heterogeneity","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Institut National Du Cancer; Hospital for Sick Children; Government of Ontario; Deutsche Krebshilfe; Terry Fox Research Institute; Studienstiftung des Deutschen Volkes; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Brain Tumour Charity; Cancer Research UK; Stand Up To Cancer; Genome British Columbia; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; National Cancer Institute; University of Toronto; USC Norris Comprehensive Cancer Center; Genome Canada","keywords":"Sonic hedgehog; Medulloblastoma; Biology; PTCH1; Patched; Hedgehog; Carcinogenesis; Progenitor cell; Computational biology; Cancer research; Neuroscience; Gene; Stem cell; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291657,0.0001130806,0.000119755,0.0002937963,0.000128979,0.0003554767,0.0001450862,0.0001150642,0.0004300202],"category_scores_gemma":[0.0002316032,0.0001260528,0.0001496716,0.0001861294,0.0002609155,0.0001667079,0.0002253847,0.0001764956,0.00008072625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004303646,"about_ca_system_score_gemma":0.0002444961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00244765,"about_ca_topic_score_gemma":0.005042239,"domain_scores_codex":[0.9999095,0.000008596939,0.00000519757,0.00003251659,0.00002907827,0.00001507548],"domain_scores_gemma":[0.999889,0.000026913,0.00004711591,0.00000971292,0.00001237786,0.00001480947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007556187,0.000004742526,0.01689446,0.00003485773,0.00002429172,0.0001744476,0.00005472867,0.003621635,0.9735363,0.001847963,0.00008545299,0.003645601],"study_design_scores_gemma":[0.00001288347,0.0001365099,0.2525788,0.00001440469,0.00009771257,0.000834701,0.0002463384,0.06569964,0.6698418,0.005091276,0.005404524,0.00004148865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892477,0.0002316854,0.009118918,0.00003383833,0.000002976758,0.000007678364,0.0003758438,0.0001007462,0.000880516],"genre_scores_gemma":[0.9971932,0.0001130834,0.002180719,0.000008767958,0.000001529183,0.000004757827,0.0002676181,0.00002165488,0.0002087705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00244765,"threshold_uncertainty_score":0.004866838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780683974207817,"score_gpt":0.3107705891926665,"score_spread":0.2929637494505883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}