{"id":"W4390672145","doi":"10.1128/spectrum.03109-22","title":"Multimodal vaccination targeting the receptor binding domains of <i>Clostridioides difficile</i> toxins A and B with an attenuated <i>Salmonella</i> Typhimurium vector (YS1646) protects mice from lethal challenge","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; McGill University; Faculty of Medicine, McGill University; Government of Canada","keywords":"Vaccination; Immunology; Salmonella enterica; Salmonella; Mesenteric lymph nodes; Antigen; Medicine; Biology; Virology; Microbiology; Immune system; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004553211,0.0004133976,0.000583928,0.0002427131,0.0002469015,0.00007031799,0.0002479401,0.0002808431,0.00022312],"category_scores_gemma":[0.0001146524,0.0002757321,0.000124964,0.0005636186,0.0002956167,0.0001162501,0.000153253,0.000872983,0.00007265665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216349,"about_ca_system_score_gemma":0.0002329024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006039661,"about_ca_topic_score_gemma":0.0002308041,"domain_scores_codex":[0.9975075,0.0002460284,0.0004915607,0.0008571363,0.0002096663,0.0006881556],"domain_scores_gemma":[0.9987518,0.0003955456,0.0001444164,0.0004235177,0.0001156069,0.0001691455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001106921,0.0003069825,0.0005351721,0.0002079187,0.0003018686,0.0001363872,0.0007692241,0.000008000056,0.994937,0.00006984172,0.000676042,0.0009446274],"study_design_scores_gemma":[0.001960515,0.002134289,0.0007063576,0.0003155023,0.0001732721,0.000288675,0.0007840584,0.0006777456,0.9894236,0.00002336754,0.003158206,0.0003544195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872107,0.0037526,0.00005547902,0.006497495,0.0002534648,0.001241128,0.0005613733,0.0001824389,0.0002453406],"genre_scores_gemma":[0.9974987,0.0004616671,0.0003904182,0.00006847833,0.0005632796,0.00006210274,0.0006820298,0.00008305089,0.0001903062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01028799,"threshold_uncertainty_score":0.9999695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01260875437766299,"score_gpt":0.2536015640993309,"score_spread":0.2409928097216679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}