{"id":"W4390672145","doi":"10.1128/spectrum.03109-22","title":"Multimodal vaccination targeting the receptor binding domains of <i>Clostridioides difficile</i> toxins A and B with an attenuated <i>Salmonella</i> Typhimurium vector (YS1646) protects mice from lethal challenge","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; McGill University; Faculty of Medicine, McGill University; Government of Canada","keywords":"Vaccination; Immunology; Salmonella enterica; Salmonella; Mesenteric lymph nodes; Antigen; Medicine; Biology; Virology; Microbiology; Immune system; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678178,0.0006207878,0.0003482427,0.0002597995,0.0001249639,0.0002348967,0.0002323011,0.0003775182,0.001008247],"category_scores_gemma":[0.00007280745,0.0001594662,0.0003231477,0.0001026746,0.000194577,0.0001997802,0.0001677928,0.000870311,0.0002221582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539704,"about_ca_system_score_gemma":0.0002270011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005317002,"about_ca_topic_score_gemma":0.0008013517,"domain_scores_codex":[0.9998405,0.0000199787,0.00001302995,0.00003359195,0.00003203774,0.00006086378],"domain_scores_gemma":[0.9998745,0.000009134828,0.00004990975,0.000009478802,0.00001129446,0.00004560133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000510872,0.0003114468,0.0001571164,0.00003081792,0.000006915312,0.00001783808,0.000006103882,0.00009218464,0.9972939,0.00003056657,0.00004908891,0.001493176],"study_design_scores_gemma":[0.0001380465,0.01545861,0.004126351,0.00001519076,0.00005007906,0.0002232676,0.00003201297,0.001016706,0.977444,0.00002374364,0.001464335,0.000007631686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977971,0.0002618124,0.001169411,0.00003952222,0.0000320458,0.00005361306,0.0001666565,0.00007116523,0.0004088586],"genre_scores_gemma":[0.9938468,0.000332537,0.002479383,0.0000624956,0.00002024136,0.0000700015,0.000486056,0.00001632651,0.002686026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001008247,"threshold_uncertainty_score":0.003372908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01260875437766299,"score_gpt":0.2536015640993309,"score_spread":0.2409928097216679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}