{"id":"W4390673873","doi":"10.7554/elife.93260.1.sa2","title":"eLife Assessment: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Partenariat Canadien Contre Le Cancer; Heart and Stroke Foundation of Canada","keywords":"Offspring; dNaM; Pregnancy; Epigenetics; Medicine; DNA methylation; Cord blood; Birth weight; Demography; Obstetrics; Physiology; Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0008428471,0.0003267424,0.0003202998,0.0005261886,0.0003641795,0.000585952,0.0005872144,0.0004228524,0.007166866],"category_scores_gemma":[0.003097383,0.0002047588,0.0005330749,0.0006368145,0.0001996747,0.0001965562,0.000969831,0.0004656787,0.0009578545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001770398,"about_ca_system_score_gemma":0.0003481245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009394716,"about_ca_topic_score_gemma":0.01417668,"domain_scores_codex":[0.9995791,0.0001106458,0.00002952277,0.0001646522,0.00005736389,0.00005865628],"domain_scores_gemma":[0.9992161,0.000214669,0.0002295243,0.0000915995,0.0001302652,0.0001177921],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005507605,0.00002430654,0.9728284,0.00006425771,0.0004380323,0.0001767471,0.0001509893,0.0003074025,0.003565867,0.0002030338,0.002181366,0.01950887],"study_design_scores_gemma":[0.00006272469,0.0001899817,0.9884049,0.00003190023,0.0004311681,0.000764703,0.0002253686,0.002440137,0.002361072,0.0004460905,0.004626332,0.00001561143],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.977991,0.0004057325,0.006486888,0.000421732,0.00003985022,0.00003514376,0.009916286,0.0003589537,0.004344419],"genre_scores_gemma":[0.9820036,0.0001768429,0.006697339,0.0001898328,0.00002460697,0.00007919025,0.005828816,0.00008431856,0.004915379],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9991571,"threshold_uncertainty_score":0.02397555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0350804742800104,"score_gpt":0.3329658348913007,"score_spread":0.2978853606112902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}