{"id":"W4390674727","doi":"10.7554/elife.88087.3","title":"Identification of 1600 replication origins in S. cerevisiae","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Origin recognition complex; Micrococcal nuclease; Origin of replication; DNA replication; Biology; Minichromosome maintenance; Chromatin; Nucleosome; Pre-replication complex; Genetics; Control of chromosome duplication; Replication (statistics); DNA; Eukaryotic DNA replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188339,0.0003861234,0.0002831111,0.001020629,0.0002424232,0.0004723512,0.0001921712,0.0002996923,0.001025722],"category_scores_gemma":[0.000323377,0.0002385938,0.0003147568,0.0005302345,0.0001310087,0.0001258839,0.00022317,0.0002540641,0.0005780009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003476047,"about_ca_system_score_gemma":0.0002823954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002356204,"about_ca_topic_score_gemma":0.004103958,"domain_scores_codex":[0.9998989,0.000007619022,0.00001431646,0.00003639789,0.00003055906,0.00001224774],"domain_scores_gemma":[0.9996943,0.00007485307,0.00005723344,0.0000276954,0.00005560158,0.00009030467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003222339,0.00003326351,0.009314706,0.0001054686,0.00002430686,0.0001401953,0.0000743085,0.0002395882,0.9846288,0.0001091726,0.00009247127,0.004915559],"study_design_scores_gemma":[0.0001052353,0.0006303994,0.2376097,0.00009466067,0.0001527108,0.001356066,0.0003291247,0.007356335,0.7366587,0.0004980012,0.01513247,0.00007669035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918188,0.001407052,0.003054778,0.00002460591,0.00002617712,0.00005143711,0.002701321,0.0002192825,0.0006966735],"genre_scores_gemma":[0.9726468,0.0006824009,0.0161268,0.00004177098,0.00001197944,0.00003274698,0.008893589,0.00006197181,0.00150191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002356204,"threshold_uncertainty_score":0.004685044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997479470032261,"score_gpt":0.3387617001694074,"score_spread":0.3187869054690848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}