{"id":"W4390675771","doi":"10.1016/j.eclinm.2023.102364","title":"Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial","year":2024,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; Population Health Research Institute","funders":"","keywords":"Medicine; Placebo; Artery; Coronary artery bypass surgery; Double blind; Internal medicine; Cardiology; Surgery; Anesthesia; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002567323,0.0003081456,0.000914061,0.0002844932,0.00005028989,0.00002444964,0.0001308368,0.0002868198,0.0000969359],"category_scores_gemma":[0.004522008,0.0002333359,0.0005674406,0.0002447391,0.0001324924,0.00001208558,0.00005187105,0.0002572755,0.00001436889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004934309,"about_ca_system_score_gemma":0.0004628797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008359131,"about_ca_topic_score_gemma":0.00002781809,"domain_scores_codex":[0.9965554,0.0008514037,0.001241804,0.0006320721,0.0003255051,0.0003937725],"domain_scores_gemma":[0.9923176,0.006824169,0.0002257934,0.000353643,0.00006294431,0.0002158786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.976042,0.001224715,0.0008848617,0.0001587237,0.001035001,0.0001107653,0.0000539577,0.00001975611,0.01469885,0.00000148153,0.004771016,0.0009989288],"study_design_scores_gemma":[0.9751874,0.006176111,0.002321904,0.0008747969,0.0003413923,0.000008595411,0.00005126612,0.0002668285,0.01372711,0.000010209,0.0007517036,0.0002826471],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939789,0.0008822679,0.00005556789,0.0003992564,0.001290053,0.003247894,0.00002046632,0.00002939079,0.00009626852],"genre_scores_gemma":[0.9978443,0.0001759271,0.00005933575,0.0005057224,0.0004292866,0.0003834882,0.0003345411,0.00004492682,0.0002225068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005972766,"threshold_uncertainty_score":0.9515161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232435914924204,"score_gpt":0.3288853111924128,"score_spread":0.3065609520431708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}