{"id":"W4390685733","doi":"10.20944/preprints202401.0591.v1","title":"History, Development and Characteristics of CRISPR-Cas System","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"CRISPR; Cas9; Biology; Genome editing; DNA; Computational biology; Genetic enhancement; Gene; Somatic cell; Palindrome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008802627,0.0006786524,0.0007823752,0.002892641,0.000726562,0.001651708,0.001062611,0.001158844,0.004367078],"category_scores_gemma":[0.001691386,0.0004802159,0.0005626314,0.002546198,0.0008708058,0.001665512,0.0009332008,0.001879624,0.003442975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001106121,"about_ca_system_score_gemma":0.001319251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002454458,"about_ca_topic_score_gemma":0.001317814,"domain_scores_codex":[0.9985219,0.0001676049,0.0001960903,0.0003831848,0.000637761,0.00009356763],"domain_scores_gemma":[0.9990934,0.000290645,0.0001136866,0.00007548502,0.0003401894,0.00008652998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002639017,0.0001105206,0.003586571,0.00419339,0.00009639349,0.001077855,0.0004566198,0.0026598,0.05449722,0.03200711,0.04544643,0.8556043],"study_design_scores_gemma":[0.00001766545,0.0001554359,0.00224881,0.0005679983,0.00006147887,0.003392552,0.0001296275,0.001553808,0.02508394,0.006015033,0.9606287,0.0001448829],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02395486,0.5343217,0.2165273,0.008908733,0.004110322,0.0009917867,0.005434476,0.005090404,0.2006605],"genre_scores_gemma":[0.1254589,0.5767693,0.1949732,0.005254116,0.001685891,0.0009532992,0.006885184,0.0009129866,0.08710717],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004367078,"threshold_uncertainty_score":0.01460934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04971436745339349,"score_gpt":0.327531946889329,"score_spread":0.2778175794359355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}