{"id":"W4390693969","doi":"10.7554/elife.93077.1","title":"A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRviii, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children","keywords":"Zebrafish; Biology; Cancer research; Microglia; Tumor microenvironment; Immune system; Innate immune system; Mesenchymal stem cell; Inflammation; Immunology; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002429327,0.0006265608,0.0003346003,0.0005925114,0.0002907377,0.0002649576,0.0003851354,0.0005179686,0.002222629],"category_scores_gemma":[0.00009662665,0.0002606594,0.0004027502,0.0001699163,0.0005460284,0.0002802462,0.0003311583,0.0009487298,0.0005671154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000868623,"about_ca_system_score_gemma":0.0008058405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004844065,"about_ca_topic_score_gemma":0.007732164,"domain_scores_codex":[0.999795,0.00001370165,0.00001654278,0.00005198862,0.00006794731,0.00005479009],"domain_scores_gemma":[0.999871,0.00001038216,0.00004807866,0.00001370947,0.00001557325,0.00004124031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008276436,0.00002222743,0.0001074293,0.00003045117,0.000004539311,0.0001058397,0.00002177416,0.0001378043,0.9982737,0.0003536763,0.0001052519,0.0007545859],"study_design_scores_gemma":[0.00003956891,0.0003684052,0.001571154,0.00001195903,0.00002813487,0.0003478054,0.00004390991,0.001532981,0.9923804,0.0001156175,0.003548063,0.00001205468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728099,0.0007798038,0.01760928,0.0004581195,0.0001274813,0.0002322964,0.002896308,0.0007207348,0.004366078],"genre_scores_gemma":[0.9723247,0.000746811,0.0112117,0.00009067418,0.00001004755,0.0003258304,0.001098163,0.000156662,0.01403532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004844065,"threshold_uncertainty_score":0.009631753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067506338291189,"score_gpt":0.2672384504363893,"score_spread":0.2565633870534774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}