{"id":"W4390704499","doi":"10.1084/jem.20230124","title":"Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway","year":2024,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; NGM Biopharmaceuticals","keywords":"Innate lymphoid cell; Biology; Immune system; Cell biology; Innate immune system; Homeostasis; Cancer research; Population; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001068254,0.0003269958,0.000231595,0.000289586,0.000244274,0.0005587627,0.0002117315,0.000193434,0.001411059],"category_scores_gemma":[0.000111565,0.0001505483,0.0001739354,0.0002025719,0.0002165802,0.0002198896,0.0003710181,0.0006280425,0.0005213505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005046213,"about_ca_system_score_gemma":0.000537121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313451,"about_ca_topic_score_gemma":0.002145606,"domain_scores_codex":[0.999842,0.00001668532,0.000008418754,0.00003311113,0.00004942303,0.00005015251],"domain_scores_gemma":[0.9999182,0.000005747883,0.0000264562,0.00001030653,0.00001178919,0.00002742525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114459,0.0000109247,0.000401454,0.00004051716,0.000004029794,0.00002878203,0.000007727785,0.0001331812,0.9975538,0.0001259124,0.0001495442,0.001432752],"study_design_scores_gemma":[0.00002534727,0.00007600203,0.009005751,0.00001260878,0.00002280298,0.0002618313,0.0000615805,0.002750634,0.9790757,0.0001879356,0.008513647,0.000006205658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852242,0.002982017,0.005934886,0.0003040213,0.00005104485,0.00002762422,0.001654834,0.0003420382,0.003479327],"genre_scores_gemma":[0.9902497,0.00107438,0.001796229,0.00009223365,0.00001077179,0.00003661834,0.001838914,0.00007954602,0.004821594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411059,"threshold_uncertainty_score":0.004720449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795944454521875,"score_gpt":0.2837418073963227,"score_spread":0.265782362851104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}