{"id":"W4390706125","doi":"10.1093/cei/uxad138","title":"Effect of the ketone beta-hydroxybutyrate on markers of inflammation and immune function in adults with type 2 diabetes","year":2024,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Diet and metabolism studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC","keywords":"Inflammation; Internal medicine; Endocrinology; Ex vivo; In vivo; Type 2 diabetes; Ketone bodies; Cytokine; Medicine; Monocyte; Immune system; Diabetes mellitus; Tumor necrosis factor alpha; Proinflammatory cytokine; Secretion; Ingestion; Metformin; Immunology; Metabolism; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004157186,0.0001154846,0.0004654486,0.00006643168,0.00002045487,0.000003185297,0.00004639509,0.00009657551,0.0000238886],"category_scores_gemma":[0.0001229866,0.0000641312,0.0000854661,0.0001654247,0.0004714785,0.00004388056,0.0000716946,0.0002027307,0.000006530528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001629739,"about_ca_system_score_gemma":0.00002207753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001679498,"about_ca_topic_score_gemma":0.000002210418,"domain_scores_codex":[0.998993,0.0001915556,0.0004250369,0.0001811316,0.00008909676,0.0001201419],"domain_scores_gemma":[0.999302,0.0003774173,0.00009632385,0.0001775744,0.00002893452,0.00001771933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0224979,0.0004072009,0.101897,0.000471406,0.001023295,0.000008093425,0.0009630842,0.000001934786,0.8148128,0.0007654091,0.00007311936,0.05707881],"study_design_scores_gemma":[0.002942681,0.01251393,0.4642428,0.0008090163,0.0001558264,0.00000156564,0.0002960088,0.00005161765,0.5186276,0.00001888666,0.0002725461,0.00006755778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794921,0.01827325,2.476029e-7,0.0001846295,0.0008433264,0.0003621603,0.000001593214,0.00001603024,0.0008266499],"genre_scores_gemma":[0.9991701,0.0005981083,0.000009302148,0.00002482212,0.00004691132,0.00002712209,0.000007273345,0.0000115324,0.0001047854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3623458,"threshold_uncertainty_score":0.2615194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114165584919287,"score_gpt":0.3169283807378369,"score_spread":0.3055118222459082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}