{"id":"W4390706303","doi":"10.1038/s41568-023-00650-x","title":"The role of CRAF in cancer progression: from molecular mechanisms to precision therapies","year":2024,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; McGill University; Jewish General Hospital","funders":"","keywords":"Kinase; Cancer research; Biology; Cancer; Melanoma; Protein kinase A; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009102504,0.001265932,0.001933082,0.001728837,0.0003010205,0.001476275,0.00144676,0.002059832,0.00435625],"category_scores_gemma":[0.0007714494,0.0004325334,0.0006977355,0.001746998,0.001072724,0.001610965,0.001090537,0.00496821,0.003592553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001433228,"about_ca_system_score_gemma":0.001174604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001419327,"about_ca_topic_score_gemma":0.003335298,"domain_scores_codex":[0.9997807,0.00003519219,0.00001860198,0.00003340118,0.0000931173,0.00003897899],"domain_scores_gemma":[0.99954,0.0002101293,0.00005002684,0.0000166971,0.0001095863,0.00007359328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002040825,0.00007382503,0.0001232626,0.008303293,0.00008267428,0.0001608619,0.00002635945,0.0007499927,0.002577474,0.009617771,0.1202973,0.8577833],"study_design_scores_gemma":[0.00005100082,0.00009038091,0.0004501633,0.001746143,0.00007290283,0.0006312947,0.00002545016,0.0001896612,0.0003858148,0.003970084,0.9923667,0.00002032854],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004280938,0.998221,0.0001219031,0.0006687487,0.000357861,0.000002634849,0.00001651965,0.000009390065,0.0005590966],"genre_scores_gemma":[0.0004166965,0.9981161,0.0001052175,0.0004227057,0.0003347805,0.000005767549,0.00002682593,0.00000165206,0.0005703526],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00435625,"threshold_uncertainty_score":0.01457304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771481328387154,"score_gpt":0.3775253980591537,"score_spread":0.3598105847752822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}