{"id":"W4390706597","doi":"10.1182/blood.2023022499","title":"BCMA- or GPRC5D-targeting bispecific antibodies in multiple myeloma: efficacy, safety, and resistance mechanisms","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Terry Fox Foundation; Sanofi; Pfizer; Amgen; Multiple Myeloma Research Foundation","keywords":"Multiple myeloma; Bispecific antibody; Antibody; Medicine; Immunology; Chimeric antigen receptor; Antigen; Cancer research; Immune system; Oncology; Monoclonal antibody; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001218837,0.0002565846,0.0003763839,0.0003023107,0.0001372828,0.0005435753,0.0003858896,0.0004132294,0.001322012],"category_scores_gemma":[0.0004726969,0.0001042017,0.0002193619,0.0003950628,0.0004003299,0.0004945794,0.0002947477,0.001055554,0.0003851264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009275754,"about_ca_system_score_gemma":0.0004596073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007048404,"about_ca_topic_score_gemma":0.001031365,"domain_scores_codex":[0.9996935,0.00008224485,0.00002151369,0.00003964146,0.00009012994,0.0000729221],"domain_scores_gemma":[0.9998158,0.0000437376,0.00006073181,0.00002240572,0.00002309494,0.00003419715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.008993863,0.001935177,0.00910227,0.0009268458,0.0002971821,0.0004260275,0.0001790108,0.003600107,0.440444,0.004990864,0.005044549,0.5240601],"study_design_scores_gemma":[0.004610027,0.05061434,0.0673411,0.0003196375,0.001031107,0.007251497,0.0002613873,0.01304229,0.7145177,0.003504242,0.1373973,0.0001093768],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.891987,0.09616312,0.003264347,0.002208318,0.0001126558,0.0001162576,0.0002507921,0.0001572146,0.005740265],"genre_scores_gemma":[0.9849088,0.0117102,0.001310349,0.0004477152,0.0000538004,0.00004514946,0.0002406145,0.00001202241,0.001271315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322012,"threshold_uncertainty_score":0.006730139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855454848661864,"score_gpt":0.296561545064348,"score_spread":0.2680069965777294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}