{"id":"W4390706597","doi":"10.1182/blood.2023022499","title":"BCMA- or GPRC5D-targeting bispecific antibodies in multiple myeloma: efficacy, safety, and resistance mechanisms","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Terry Fox Foundation; Sanofi; Pfizer; Amgen; Multiple Myeloma Research Foundation","keywords":"Multiple myeloma; Bispecific antibody; Antibody; Medicine; Immunology; Chimeric antigen receptor; Antigen; Cancer research; Immune system; Oncology; Monoclonal antibody; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003167104,0.0002223632,0.0003727003,0.0002696911,0.0001325331,0.00008160756,0.00008461164,0.00009544644,0.0001324156],"category_scores_gemma":[0.0004631546,0.0001596578,0.00007127146,0.0004091572,0.00008513501,0.0001029826,0.00009764486,0.0002641116,0.00009736548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006165458,"about_ca_system_score_gemma":0.0001150075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006099416,"about_ca_topic_score_gemma":0.0003927516,"domain_scores_codex":[0.998226,0.00006572541,0.0003353697,0.0005217309,0.0003560729,0.0004951336],"domain_scores_gemma":[0.9990306,0.0004348615,0.00003108895,0.0002557688,0.00004537206,0.0002023293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01669371,0.00993414,0.4292692,0.007897045,0.003580279,0.06663737,0.006380864,0.0000100112,0.3324331,0.01674854,0.005700393,0.1047153],"study_design_scores_gemma":[0.05024933,0.00134397,0.8129109,0.004671698,0.0005863562,0.0005857451,0.001415066,0.002237892,0.08502311,0.00201183,0.03781887,0.00114522],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810118,0.01283366,0.0002354394,0.001024717,0.00015849,0.0008931538,0.00007048772,0.0002461195,0.003526097],"genre_scores_gemma":[0.9860754,0.001782982,0.008620118,0.00003040393,0.0001160345,0.0000303695,0.00006359678,0.00004525665,0.003235839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3836417,"threshold_uncertainty_score":0.6510656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855454848661864,"score_gpt":0.296561545064348,"score_spread":0.2680069965777294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}