{"id":"W4390706866","doi":"10.4049/immunohorizons.2300101","title":"Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl–Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation","year":2024,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Diabetes Canada; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto","keywords":"AKT2; Chemistry; ATP citrate lyase; Glycolysis; Biochemistry; Inflammation; Histone H3; Protein kinase B; Phosphorylation; Acetylation; Biology; AKT1; Enzyme; Citrate synthase; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993055,0.0004159216,0.0003396894,0.0003061044,0.0001626101,0.0002510893,0.0001512707,0.0002062733,0.001029848],"category_scores_gemma":[0.00008248701,0.0001977007,0.000353759,0.000231775,0.0002824,0.0001706769,0.0002111176,0.0005017007,0.0003287102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001895773,"about_ca_system_score_gemma":0.0003310797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000454075,"about_ca_topic_score_gemma":0.000575637,"domain_scores_codex":[0.9998029,0.00002595155,0.00002340856,0.0000335651,0.00003880097,0.00007539424],"domain_scores_gemma":[0.9998826,0.000008483467,0.00003824045,0.00001170742,0.00001609595,0.00004280477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005540745,0.00005458067,0.0001831617,0.00003893651,0.000005424341,0.00002255555,0.00001319213,0.00002269332,0.9986492,0.00003740337,0.00001698233,0.000401767],"study_design_scores_gemma":[0.00007845891,0.0008153248,0.01132472,0.00001245923,0.00002751077,0.0001291588,0.00006440904,0.0007027074,0.9856461,0.00008370821,0.001107828,0.000007596992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971827,0.001088553,0.0008063195,0.00006576489,0.00003376797,0.00001820292,0.0003126595,0.00003344172,0.0004586622],"genre_scores_gemma":[0.9953603,0.001004924,0.001016649,0.00007047452,0.00001289866,0.0000727939,0.0005706257,0.00001446511,0.001876778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029848,"threshold_uncertainty_score":0.003445208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892497497207371,"score_gpt":0.2852561079705962,"score_spread":0.2663311329985225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}