{"id":"W4390706866","doi":"10.4049/immunohorizons.2300101","title":"Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl–Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation","year":2024,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Diabetes Canada; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto","keywords":"AKT2; Chemistry; ATP citrate lyase; Glycolysis; Biochemistry; Inflammation; Histone H3; Protein kinase B; Phosphorylation; Acetylation; Biology; AKT1; Enzyme; Citrate synthase; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007383212,0.0003150402,0.0005514543,0.0005413039,0.0001109273,0.00007436593,0.00009059496,0.0002519041,0.00003698325],"category_scores_gemma":[0.0004331535,0.0002986437,0.0001365995,0.0006390986,0.00009828939,0.0006867202,0.00007817357,0.0004237375,0.00001575034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000169171,"about_ca_system_score_gemma":0.0002368399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008056622,"about_ca_topic_score_gemma":0.0001262579,"domain_scores_codex":[0.997812,0.0001239419,0.0007544435,0.0005855773,0.0003963042,0.0003276761],"domain_scores_gemma":[0.9988504,0.00008226576,0.000213389,0.0005179992,0.000225131,0.0001107863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000585382,0.0001306966,0.00113085,0.000379023,0.0001158817,0.00001340047,0.001865284,0.00003077008,0.9812356,0.0001612116,0.00008142692,0.01427045],"study_design_scores_gemma":[0.001554387,0.0001764881,0.1679316,0.0007152608,0.0001315679,0.00006226966,0.0002211805,0.0007651229,0.8278182,0.0001769327,0.0002153261,0.0002317083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945909,0.001381144,0.0002619881,0.001335966,0.0008481834,0.00132591,0.00001138311,0.0002147411,0.00002979767],"genre_scores_gemma":[0.9981837,0.0003182313,0.0004085523,0.00004350536,0.0006456806,0.00009301941,0.00005945248,0.00005822882,0.0001896788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1668008,"threshold_uncertainty_score":0.9999466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892497497207371,"score_gpt":0.2852561079705962,"score_spread":0.2663311329985225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}