{"id":"W4390707166","doi":"10.1093/infdis/jiad609","title":"Unraveling the Immune Signature of Herpes Zoster: Insights Into the Pathophysiology and Human Leukocyte Antigen Risk Profile","year":2024,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Irving Medical Center, Columbia University; Fonds Wetenschappelijk Onderzoek; Meyer Foundation; Vlaamse Interuniversitaire Raad; Fondation pour la Recherche Médicale; SCOR Corporate Foundation for Science; National Institutes of Health; Fisher Center for Alzheimer's Research Foundation; Fondation du Souffle; Université de Paris; Rockefeller University; Agence Nationale de la Recherche; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Immunology; Shingles; Immune system; Varicella zoster virus; Human leukocyte antigen; Biology; Major histocompatibility complex; Antigen; Innate immune system; Virus; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004039603,0.0002489763,0.0002986965,0.0006229898,0.0001363534,0.0006582977,0.0001857241,0.0002683229,0.001381611],"category_scores_gemma":[0.0007542565,0.0001068533,0.0002104103,0.0006004594,0.0002361838,0.0004904348,0.000366304,0.0005174562,0.0001974335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965987,"about_ca_system_score_gemma":0.0002643439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006633862,"about_ca_topic_score_gemma":0.0008618613,"domain_scores_codex":[0.9998374,0.00005299946,0.00001406839,0.00003948394,0.00002578393,0.0000303064],"domain_scores_gemma":[0.999778,0.0000612782,0.00007829285,0.00002860284,0.00002241605,0.00003141311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001039759,0.0001310309,0.6622589,0.0006096468,0.0003491474,0.0009473436,0.0007089513,0.0007118561,0.2178199,0.00175457,0.001295371,0.1123735],"study_design_scores_gemma":[0.00003155085,0.0003883462,0.973044,0.0001150212,0.0001951901,0.002132518,0.0006232207,0.001368908,0.01095048,0.002668265,0.008460408,0.0000220142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765301,0.01720767,0.003137678,0.001175759,0.00004304937,0.00001958857,0.0006915807,0.00002145086,0.001173169],"genre_scores_gemma":[0.9931285,0.003859763,0.001840433,0.000311326,0.0000742264,0.00001195792,0.0003575787,0.00000566272,0.0004105141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381611,"threshold_uncertainty_score":0.004621923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006008101903415295,"score_gpt":0.2631883466476904,"score_spread":0.2571802447442751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}