{"id":"W4390726324","doi":"10.1158/1538-7445.dnarepair24-b001","title":"Abstract B001: Identification of monoallelic <i>ATM</i> loss-of-function and homologous recombination deficiency (HRD) in high-grade ovarian tumor with prolonged response to camonsertib and low-dose gemcitabine combination therapy","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"","keywords":"Carboplatin; Medicine; Gemcitabine; Debulking; Olaparib; Internal medicine; Oncology; Ovarian cancer; Neutropenia; Progressive disease; Cisplatin; Surgery; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646619,0.0002499374,0.0002404523,0.0005075362,0.000294956,0.0004234104,0.0002552078,0.0006537585,0.002196328],"category_scores_gemma":[0.0003503322,0.0001432599,0.000196023,0.0002474746,0.0002620734,0.0001707277,0.0001945564,0.0004531133,0.0005986901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894883,"about_ca_system_score_gemma":0.0001505754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006855871,"about_ca_topic_score_gemma":0.0007004067,"domain_scores_codex":[0.999913,0.000008826466,0.00001023539,0.00002441248,0.00001515713,0.00002843805],"domain_scores_gemma":[0.9997943,0.00003773624,0.00005043281,0.0000142238,0.00001980164,0.00008357831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.003657365,0.0004444376,0.3120273,0.0001591643,0.00006115282,0.518334,0.0003481681,0.0003629796,0.1399385,0.0005121889,0.002997336,0.02115748],"study_design_scores_gemma":[0.0001501337,0.001734264,0.3924398,0.0000270062,0.00009494931,0.5742482,0.0003120576,0.002984596,0.02239595,0.0002656395,0.005331126,0.00001617595],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966366,0.0004478715,0.0003677976,0.000285023,0.00002424341,0.00003965306,0.0002055088,0.00003248832,0.001960846],"genre_scores_gemma":[0.9992439,0.00007263484,0.0001549302,0.00005659317,0.00001913979,0.000003792808,0.0001297651,0.0000052293,0.000313991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002196328,"threshold_uncertainty_score":0.007347524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04393376931211829,"score_gpt":0.3678654818521156,"score_spread":0.3239317125399974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}