{"id":"W4390731618","doi":"10.1016/j.scr.2024.103308","title":"Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)","year":2024,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Canadian Institutes of Health Research; Association Française contre les Myopathies","keywords":"Dilated cardiomyopathy; Biology; Cardiomyopathy; Internal medicine; Control line; Line (geometry); Cardiology; Heart failure; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006949957,0.0002922821,0.0003758324,0.0001956326,0.0001464322,0.0001623406,0.0001412892,0.0002072801,0.0000124156],"category_scores_gemma":[0.00000620871,0.0002462888,0.0001092538,0.0002313366,0.0001942054,0.00001970079,0.00009848416,0.0003299569,0.000006028969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003112065,"about_ca_system_score_gemma":0.0001284858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006002191,"about_ca_topic_score_gemma":0.00001539346,"domain_scores_codex":[0.9975597,0.0003062203,0.0003698311,0.000744295,0.0004930978,0.0005269055],"domain_scores_gemma":[0.998862,0.00005366627,0.00005532656,0.0004675339,0.0002783406,0.0002831366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003635279,0.00005378432,0.001191706,0.0002469319,0.0001538472,0.00006366659,0.0005283175,0.002027076,0.9853013,0.0000174116,0.0002554608,0.009796986],"study_design_scores_gemma":[0.003809757,0.00410977,0.00143804,0.0001226442,0.000150849,0.00009920642,0.0006664525,0.02355627,0.9465317,0.00001286562,0.01883285,0.0006695568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527297,0.04015721,0.005661156,0.00004511181,0.0001713616,0.0007271038,0.0002002121,0.00002675875,0.000281363],"genre_scores_gemma":[0.9961106,0.00276649,0.0001360051,0.000017805,0.0004890232,0.00007791586,0.0001125546,0.0000650632,0.0002245355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04338089,"threshold_uncertainty_score":0.9999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02261196776991389,"score_gpt":0.2978000596178302,"score_spread":0.2751880918479164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}