{"id":"W4390731618","doi":"10.1016/j.scr.2024.103308","title":"Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)","year":2024,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Canadian Institutes of Health Research; Association Française contre les Myopathies","keywords":"Dilated cardiomyopathy; Biology; Cardiomyopathy; Internal medicine; Control line; Line (geometry); Cardiology; Heart failure; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006143317,0.0003957555,0.0004739767,0.000423928,0.0003656531,0.0003727791,0.000560261,0.0008679087,0.002417276],"category_scores_gemma":[0.0003804831,0.0002283181,0.0004358634,0.0003732113,0.0002612875,0.0001420368,0.0003873932,0.001072452,0.001423367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935023,"about_ca_system_score_gemma":0.0004543997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006106526,"about_ca_topic_score_gemma":0.0007590207,"domain_scores_codex":[0.99963,0.0000277427,0.00007676629,0.00008773894,0.0001343665,0.00004340221],"domain_scores_gemma":[0.9997798,0.00004001218,0.00003291155,0.00005442974,0.00004103705,0.00005185898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209615,0.0001518208,0.000854224,0.0000951134,0.00001977966,0.001239489,0.0001351341,0.0003156078,0.9883705,0.001158702,0.0008200143,0.006718531],"study_design_scores_gemma":[0.0002679839,0.0006969181,0.0083186,0.00009411275,0.0001418728,0.01393213,0.0001815774,0.00427544,0.9271309,0.0004202233,0.04448717,0.00005307588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8933252,0.001363915,0.06683945,0.000595129,0.0007318544,0.00167275,0.01059686,0.0008167209,0.02405812],"genre_scores_gemma":[0.923919,0.00143361,0.04145971,0.0006200778,0.0000805947,0.00144461,0.01643278,0.0002986292,0.01431093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002417276,"threshold_uncertainty_score":0.008086562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02261196776991389,"score_gpt":0.2978000596178302,"score_spread":0.2751880918479164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}