{"id":"W4390733665","doi":"10.1002/adhm.202303256","title":"Local and Sustained Baricitinib Delivery to the Skin through Injectable Hydrogels Containing Reversible Thioimidate Adducts","year":2024,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Materials Research; Beef Cattle Research Council; University of Pennsylvania; National Science Foundation; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; LEO Fondet","keywords":"Self-healing hydrogels; Hyaluronic acid; In vivo; Imiquimod; Nanocages; Pharmacology; Cancer research; Chemistry; Medicine; Dermatology; Biochemistry; Polymer chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003365554,0.0002248169,0.0004865408,0.00009093194,0.0002658457,0.00006970374,0.0001120149,0.0001321347,0.0002003219],"category_scores_gemma":[0.0001708314,0.0001635414,0.0000483912,0.0002563124,0.0001182798,0.0002737471,0.0001306178,0.0001775984,0.0001373545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009890093,"about_ca_system_score_gemma":0.0003163126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004160432,"about_ca_topic_score_gemma":0.00006182805,"domain_scores_codex":[0.9982283,0.0001933325,0.0004064738,0.0004575723,0.0001867578,0.0005276409],"domain_scores_gemma":[0.9989984,0.0002545375,0.00005904592,0.0003417914,0.0001422619,0.0002039477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03455124,0.0008004147,0.009710191,0.04292313,0.00251074,0.01828563,0.05481252,0.0008419357,0.2501819,0.127604,0.2129367,0.2448416],"study_design_scores_gemma":[0.00549942,0.002187843,0.008478246,0.005655378,0.000664128,0.002924459,0.02660163,0.0002740697,0.5022057,0.01633405,0.4276758,0.001499316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548673,0.01175542,0.001178511,0.02888732,0.0009120294,0.001270981,0.000186845,0.0002886504,0.0006529141],"genre_scores_gemma":[0.9881576,0.0006513043,0.00106722,0.009344712,0.0001564622,0.0001082777,0.000100649,0.00004017765,0.0003736361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2520237,"threshold_uncertainty_score":0.6669026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758471357525702,"score_gpt":0.3113922989785379,"score_spread":0.2938075854032808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}