{"id":"W4390739144","doi":"10.1016/j.ekir.2024.01.006","title":"Use of Avacopan in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Estimated Glomerular Filtration Rate <15 ml/min per 1.73 m2","year":2024,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Manitoba","funders":"Sanofi","keywords":"Medicine; Anti-neutrophil cytoplasmic antibody; Renal function; Vasculitis; Rapidly progressive glomerulonephritis; Microscopic polyangiitis; Kidney; Antibody; Glomerulonephritis; Internal medicine; Gastroenterology; ANCA-Associated Vasculitis; Urology; Pathology; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002099647,0.0001900476,0.0003108757,0.0003593883,0.00004757229,0.00008248348,0.00004301618,0.0001389669,0.0003445072],"category_scores_gemma":[0.0006311859,0.0001546064,0.0001012558,0.0003013648,0.0000851014,0.0003643561,0.00003021901,0.000239124,0.00001218658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251706,"about_ca_system_score_gemma":0.0002603147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001972514,"about_ca_topic_score_gemma":0.00001734667,"domain_scores_codex":[0.9982426,0.00004769091,0.0006126384,0.0004113524,0.0004896988,0.0001960412],"domain_scores_gemma":[0.9989555,0.00006124326,0.0002080776,0.0002036836,0.0003950471,0.000176463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001620973,0.0006625268,0.9637073,0.0001800942,0.001309062,0.002678787,0.0003463875,0.0002444391,0.02364197,0.0005624899,0.005651023,0.0008538182],"study_design_scores_gemma":[0.001880782,0.0002232128,0.9861645,0.001768813,0.0002479804,0.0005033536,0.00001152849,0.003774793,0.001169635,0.0001533854,0.003905611,0.0001964118],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964818,0.0001459315,0.0000828619,0.001404842,0.0005243768,0.0003796236,0.0002168589,0.00008443523,0.0006792273],"genre_scores_gemma":[0.994505,0.0002108888,0.0004085281,0.0001789921,0.00004513171,0.00001718804,0.00371539,0.00003384439,0.000885072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02247233,"threshold_uncertainty_score":0.6304668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018967555032329,"score_gpt":0.2554784468592061,"score_spread":0.2452887713088828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}