{"id":"W4390739144","doi":"10.1016/j.ekir.2024.01.006","title":"Use of Avacopan in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Estimated Glomerular Filtration Rate <15 ml/min per 1.73 m2","year":2024,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Manitoba","funders":"Sanofi","keywords":"Medicine; Anti-neutrophil cytoplasmic antibody; Renal function; Vasculitis; Rapidly progressive glomerulonephritis; Microscopic polyangiitis; Kidney; Antibody; Glomerulonephritis; Internal medicine; Gastroenterology; ANCA-Associated Vasculitis; Urology; Pathology; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002237018,0.0001710161,0.0004516747,0.0003632163,0.0003074618,0.0002990402,0.0001893737,0.0005292593,0.0009234419],"category_scores_gemma":[0.0007925368,0.00008778131,0.0002624334,0.000457064,0.0001953794,0.0003098912,0.000186043,0.0005904543,0.0001053241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318247,"about_ca_system_score_gemma":0.0005278597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104639,"about_ca_topic_score_gemma":0.002314759,"domain_scores_codex":[0.9998391,0.00004203976,0.00001866913,0.00002044447,0.00003962584,0.00004019056],"domain_scores_gemma":[0.999667,0.00007080592,0.0001101397,0.00000658678,0.00001394296,0.0001314656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006573696,0.0009855853,0.8691853,0.0004880578,0.0002813282,0.01813754,0.0002862019,0.0003923711,0.005152908,0.0002870718,0.002687172,0.09554286],"study_design_scores_gemma":[0.0004122323,0.007158197,0.9562964,0.0002776048,0.0002875834,0.02697352,0.0004953677,0.00107266,0.0007963832,0.0005030935,0.005691655,0.00003526805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739218,0.0193946,0.00025747,0.001116453,0.000158134,0.00003309417,0.0001077254,0.00001863249,0.004992027],"genre_scores_gemma":[0.9953746,0.003409309,0.0002205544,0.0003838371,0.0001602405,0.00001352494,0.0001070862,0.00000226624,0.0003287329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104639,"threshold_uncertainty_score":0.003089249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018967555032329,"score_gpt":0.2554784468592061,"score_spread":0.2452887713088828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}