{"id":"W4390740053","doi":"10.1128/aac.01132-23","title":"<i>In vitro</i> activity of manogepix and comparators against infrequently encountered yeast and mold isolates from the SENTRY Surveillance Program (2017–2022)","year":2024,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"bioMérieux; Idorsia Pharmaceuticals; TenNor Therapeutics; Astellas Foundation for Research on Metabolic Disorders; Shionogi; Basilea Pharmaceutica; Astellas Pharma; Pfizer; Melinta Therapeutics; Entasis Therapeutics; U.S. Food and Drug Administration; Amplyx; Roivant Sciences; Nabriva Therapeutics; Albany College of Pharmacy and Health Sciences; BD; GenePOC; University of North Texas; Boston Pharmaceuticals; F. Hoffmann-La Roche; Novartis; Harvard University; Wockhardt; Allergan; Cidara Therapeutics; University of Southern California; Bayer","keywords":"Microbiology; Candida krusei; Biology; Rhodotorula; Paecilomyces; Amphotericin B; Fungi imperfecti; Yeast; Candida albicans; Candida tropicalis; Antifungal; Botany; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005233076,0.0003186405,0.0003589143,0.0003368552,0.0001396743,0.0003311615,0.0002439807,0.0002071709,0.002508911],"category_scores_gemma":[0.0004201126,0.0001382772,0.0002964434,0.0004020061,0.0001389332,0.0001742681,0.000229524,0.0002779237,0.0003861208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919528,"about_ca_system_score_gemma":0.000294888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113333,"about_ca_topic_score_gemma":0.001562546,"domain_scores_codex":[0.9995956,0.0001586291,0.00006117028,0.00005975076,0.00008426939,0.00004070123],"domain_scores_gemma":[0.9997818,0.00005134649,0.00005943654,0.00002163961,0.00005446496,0.00003130031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01095272,0.001435923,0.01335764,0.0006548745,0.0001765434,0.000379584,0.0002337074,0.002280272,0.9354394,0.0001993996,0.002092666,0.03279736],"study_design_scores_gemma":[0.0004811639,0.0407847,0.04148015,0.00007187315,0.0002711624,0.001314798,0.0002342657,0.002033256,0.897756,0.00005627756,0.01548098,0.00003536849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889199,0.003022042,0.0008805768,0.00009917266,0.00006450686,0.0002159892,0.00282553,0.00005734847,0.003915004],"genre_scores_gemma":[0.985167,0.001707422,0.002421504,0.000106187,0.00006102897,0.000110147,0.007574239,0.00001475742,0.002837733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002508911,"threshold_uncertainty_score":0.008393109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255993161547566,"score_gpt":0.2778312165937888,"score_spread":0.2652712849783132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}