{"id":"W4390740624","doi":"10.1177/09636897231221882","title":"Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm","year":2024,"lang":"en","type":"article","venue":"Cell Transplantation","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Osteoarthritis; WOMAC; Adverse effect; Tolerability; Clinical endpoint; Placebo; Knee pain; Physical therapy; Clinical trial; Surgery; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002355913,0.001074085,0.001709628,0.0003725345,0.0004874183,0.0004739779,0.0003850607,0.0008892997,0.001812535],"category_scores_gemma":[0.001030948,0.0005092759,0.0009871733,0.0002612015,0.001124852,0.0004836505,0.0003618064,0.001363757,0.0004425145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000316675,"about_ca_system_score_gemma":0.0009773844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000557681,"about_ca_topic_score_gemma":0.001012873,"domain_scores_codex":[0.9992173,0.0003999799,0.00005599874,0.0001238459,0.0001009928,0.0001018549],"domain_scores_gemma":[0.9992024,0.0002236043,0.0001717207,0.00009044032,0.0000879807,0.0002237224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5337299,0.2053304,0.02243395,0.00101748,0.0008118899,0.0005613798,0.0009935016,0.001449364,0.1497222,0.0001446482,0.0005891992,0.08321613],"study_design_scores_gemma":[0.02720258,0.958168,0.01195856,0.000007222577,0.0001500096,0.0000573106,0.00006219523,0.0001838213,0.001907616,0.0000237577,0.00026693,0.00001193963],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984854,0.0002524526,0.000268585,0.00002641749,0.00001721923,0.0007415616,0.00006837253,0.00001197782,0.0001279141],"genre_scores_gemma":[0.9959838,0.0004592386,0.001041425,0.0002149639,0.00009738892,0.001090011,0.000233259,0.00000794993,0.0008719823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355913,"threshold_uncertainty_score":0.01245946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008766362608214767,"score_gpt":0.2214887187448384,"score_spread":0.2127223561366236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}