{"id":"W4390741856","doi":"10.1016/j.neurobiolaging.2023.12.008","title":"Vascular risk burden is a key player in the early progression of Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"H2020 Marie Skłodowska-Curie Actions; National Institute on Aging; Fonds de Recherche du Québec - Santé; European Commission; Genentech; Alzheimer's Drug Discovery Foundation; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Vetenskapsrådet; Horizon 2020 Framework Programme; Alzheimer's Disease Neuroimaging Initiative; Julius Clinical; Stiftelsen för Gamla Tjänarinnor; IXICO; H. Lundbeck A/S; Servier; Siemens Healthineers; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Novo Nordisk; University of Southern California; Eisai; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Prothena; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Alzheimerfonden; Weston Brain Institute; Northern California Institute for Research and Education; Hjärnfonden; Familjen Erling-Perssons Stiftelse; Fondation Brain Canada; Meso Scale Diagnostics; Instituto Serrapilheira; Biogen; BioClinica; Alzheimer's Association; BrightFocus Foundation; Eli Lilly and Company; U.S. Department of Defense; Consortium canadien en neurodégénérescence associée au vieillissement; Bristol-Myers Squibb; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; National Academy of Neuropsychology; Novartis Pharmaceuticals Corporation","keywords":"Disease; Neurodegeneration; Context (archaeology); Pathophysiology; Medicine; Alzheimer's disease; Neuroscience; Cerebrospinal fluid; Cognitive decline; Internal medicine; Bioinformatics; Psychology; Dementia; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001005218,0.0006642286,0.0008857184,0.001279773,0.0006339414,0.003297714,0.0004460544,0.0008760953,0.003911318],"category_scores_gemma":[0.004917346,0.0003893324,0.0004052408,0.00126784,0.0003968002,0.00132714,0.001025805,0.001630977,0.0006452469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005508142,"about_ca_system_score_gemma":0.0008736852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004069701,"about_ca_topic_score_gemma":0.004170415,"domain_scores_codex":[0.9993899,0.0001581011,0.00005994705,0.000110694,0.0002025611,0.00007881823],"domain_scores_gemma":[0.9977946,0.0004643276,0.0008721234,0.0001091819,0.0004809635,0.0002787269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00167929,0.0006453733,0.7430611,0.001108828,0.0008081916,0.001616522,0.001206773,0.00105414,0.006438173,0.01124969,0.01226783,0.218864],"study_design_scores_gemma":[0.00002677236,0.0003064664,0.9663659,0.0003072718,0.0003755299,0.001767994,0.0004828116,0.001098736,0.0008653463,0.01121818,0.01713097,0.00005396453],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8170928,0.1262348,0.005944209,0.01254679,0.001077515,0.00008512867,0.003142518,0.0001877911,0.03368849],"genre_scores_gemma":[0.9589394,0.0309638,0.002864407,0.0005685535,0.001473785,0.00003036083,0.0007756538,0.00002253417,0.004361542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004069701,"threshold_uncertainty_score":0.01308465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109367221153052,"score_gpt":0.3349037730650717,"score_spread":0.3138101008535412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}