{"id":"W4390743359","doi":"10.1128/spectrum.03201-23","title":"The mechanism of action of auranofin analogs in <i>B. cenocepacia</i> revealed by chemogenomic profiling","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Canadian HIV Trials Network, Canadian Institutes of Health Research; Government of Canada; Foundation for the National Institutes of Health","keywords":"Profiling (computer programming); Mechanism of action; Mechanism (biology); Computational biology; Pharmacology; Psychology; Biology; Genetics; Computer science; Epistemology; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001584158,0.0004113457,0.0004146213,0.0004750247,0.0001890345,0.0004673334,0.0001841215,0.0003675046,0.0009943789],"category_scores_gemma":[0.0002583138,0.000156085,0.000353137,0.0006169254,0.0001930633,0.000237518,0.0002293149,0.0003704203,0.0004362269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003839913,"about_ca_system_score_gemma":0.0002625395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002327485,"about_ca_topic_score_gemma":0.002355939,"domain_scores_codex":[0.9998004,0.00001485676,0.00001166403,0.00006016863,0.00007567046,0.00003721241],"domain_scores_gemma":[0.9998424,0.00002511498,0.00005791159,0.00001256,0.00004373811,0.00001819012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009675424,0.00001711011,0.001591653,0.00006235353,0.000008119827,0.00002975794,0.00001207033,0.000152667,0.995267,0.00003179511,0.00009518756,0.002635711],"study_design_scores_gemma":[0.00002158497,0.0007568789,0.0823537,0.0000333122,0.00008471699,0.0004227101,0.0002794935,0.002674958,0.9050146,0.0001906716,0.00813101,0.00003640878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826397,0.001671825,0.002642946,0.0002409377,0.00003310144,0.00006345293,0.01042045,0.0003822328,0.001905301],"genre_scores_gemma":[0.9799985,0.001280949,0.005627309,0.0002433754,0.00001147796,0.00008482238,0.01004671,0.00006993668,0.002636868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002327485,"threshold_uncertainty_score":0.004627883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005388753799286283,"score_gpt":0.2279860727066815,"score_spread":0.2225973189073952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}