{"id":"W4390744029","doi":"10.1126/scisignal.adh1641","title":"The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease","year":2024,"lang":"en","type":"article","venue":"Science Signaling","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Immune system; Inflammation; Immunology; Inflammatory bowel disease; Biology; NF-κB; Innate immune system; Acquired immune system; Signal transduction; Gastrointestinal tract; Transcription factor; Proinflammatory cytokine; Homeostasis; Disease; Cell biology; Medicine; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005109741,0.0005873971,0.0006715094,0.0007630919,0.0003078948,0.000874821,0.0003857915,0.0006675025,0.0008418081],"category_scores_gemma":[0.000275743,0.0001219388,0.0003703084,0.0005625638,0.0005057564,0.0009602444,0.0005223632,0.002090967,0.0005501361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005817489,"about_ca_system_score_gemma":0.0008296813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00048762,"about_ca_topic_score_gemma":0.0008541348,"domain_scores_codex":[0.9997879,0.00004214998,0.00004396509,0.00003156376,0.00005865997,0.00003579597],"domain_scores_gemma":[0.9998327,0.00003106644,0.00004621929,0.000005677882,0.00004786811,0.00003632055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00128737,0.0002965938,0.007128399,0.02508033,0.0003868266,0.004651338,0.001273795,0.001551456,0.1211082,0.04088517,0.04035719,0.7559933],"study_design_scores_gemma":[0.00006892149,0.0005770478,0.01339125,0.004429124,0.0004284029,0.01107281,0.000593569,0.0006308751,0.01525326,0.02168464,0.9317799,0.00009033823],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003435325,0.9897569,0.001545736,0.002157629,0.0009875717,0.00001288258,0.0000524368,0.00002930753,0.002022146],"genre_scores_gemma":[0.03139343,0.9609026,0.002079145,0.001456779,0.002207932,0.00002559845,0.0001083174,0.000008075694,0.001818161],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.000874821,"threshold_uncertainty_score":0.004220963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006227544010579978,"score_gpt":0.2343488109669266,"score_spread":0.2281212669563467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}